摘要
目的观察特殊人群荧光素眼底血管造影的不良反应发生率及相关因素。方法使用海德堡眼底血管造影机对256例特殊人群进行造影，按体重注射荧光素钠造影剂，观察记录不良反应的情况。特殊人群是指有符合下列条件之一的患者：（1）有药物过敏史者；（2）有重要内脏器官疾病者；（3）首次检查有恶心、呕吐、瘙痒等轻度反应但需再次检查者；（4）年龄≥80岁身体健康者。结果256例特殊人群造影出现不良反应69例，占本组患者的27．0％。造影的不良反应多为轻中度。既往有药物过敏史者73例中，有10例出现恶心呕吐，喷嚏，瘙痒等反应，占该组患者的13．7％；有重要内脏器官疾病者78例中，4例有恶心呕吐反应，占该组患者的5．1％；首次检查有恶心、呕吐、瘙痒等反应但需再次检查者56例中，有54例均有不同程度的不良反应发生，占该组患者的96．4％；年龄1〉80岁身体健康者49例中有1例发生恶心反应，占该组患者的2．0％。结论FFA检查对这类特殊人群是一项安全检查，特殊人群造影的不良反应一般是轻中度，其不良反应发生率与健康人群使用荧光素钠造影不良反应相似。仔细观察患者，加强防范和抢救措施，对提高特殊人群血管造影的安全性有重要意义。
Objective To determine the incidence rate and correlation factors of the adverse reactions during fluorescence fundus angiography （FFA） in special patients. Methods 256 special patients were performed FFA with Heidelberg Retinal Angiography. Fluorescein Sodium was given according to the body weight and adverse reactions during FFA were observed. The special patients enrolled in this study include those with drug allergy history, system disease, light adverse reactions such as nansea, vomiting and pruritus during the fist FFA or patients over 80 years old. Results Adverse reactions were observed in 69 of 256 （27. 0% ） cases and the majority is at a mild to moderate degree. Nausea, sneezing, vomiting or pruritus occurred in 10 of 73 （ 13.7% ） patients with drug allergy history. Nausea or vomiting occurred in 4 of 78 （5.1% ） patients with systemic diseases. Different degrees of adverse reactions occurred in 54 of 56 （94. 6% ） cases who had nausea, vomiting or pruritus during the first FFA. Nausea occurred in 1 of 49 （2. 0% ） patients over 80 years old. Conclusion FFA is a safe examination for the above special patients. The incidence rate of adverse reaction due to FFA in these special patients is similar to that in the healthy population. Observing the patients closely and strengthening the containment and salvage measures are important to improve the safety of FFA in these special patients.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2009年第21期1490-1492,共3页
National Medical Journal of China
