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p53和PCNA与非小细胞肺癌 被引量：1

p53 and PCNA in non-small cell lung cancer
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摘要 p53基因和增殖细胞核抗原（PCNA）均与非小细胞肺癌（NSCLC）的放疗有密切关系。两者同时高表达的NSCLC患者的生存期低于同时阴性者。研究p53基因和PCNA在NSCLC中的表达，及其与NSCLC放射敏感性和预后的关系，可以对临床制定个体化治疗方案和提高疗效起到积极作用。 p53 Gene and proliferating cell nuclear antigen （PCNA） are both related closely to the radiotherapy of non-small cell lung cancer（NSCLC）. The life span of NSCLC patients with both p53 and PCNA positive is shorter than that of NSCLC patients with both 1353 and PCNA negative. Studying the expression of p53 and PCNA in NSCLC, and their relationship with the radiosensitivity and prognosis of NSCLC can play a positive role in individualized treatment and increasing curative effect.
作者 肖宝荣(综述) 朱兆峰(综述) 卢鑫(综述)
机构地区 山东省泰安市肿瘤医院放疗科
出处 《国际肿瘤学杂志》 CAS 2009年第4期283-285,共3页 Journal of International Oncology
关键词 癌 非小细胞肺 基因 p53 增殖细胞核抗原 辐射耐受性 预后 Carcinoma,non-small-cell lung Genes,p53 Proliferating cell nuclear antigen Radiation tolerance Prognosis
分类号 R734.2 [医药卫生—肿瘤] R735.2 [医药卫生—肿瘤]
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国际肿瘤学杂志
2009年 第4期

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