摘要
目的：研究细胞生长调节基因ｃ－ｆｏｓ及ｃ－ｅｒｂＢ－２在卵巢癌中表达的意义，探讨卵巢癌发生、发展的机理。方法：采用免疫组化方法对３８例卵巢癌进行检测。结果：ｃ－ｆｏｓ在卵巢癌中的阳性率为６６％（２５／３８）。ｃ－ｆｏｓ表达与卵巢癌组织学分级有关，低分化组ｃ－ｆｏｓ表达率高于高分化和中分化组（Ｐ＝０．００１５）。ｃ－ｆｏｓ表达与卵巢癌临床分期有关，Ⅲ／Ⅳ期卵巢癌ｃ－ｆｏｓ表达率较Ⅰ／Ⅱ期者高（Ｐ＝０．００６４）。ｃ－ｆｏｓ及ｃ－ｅｒｂＢ－２都与ＰＣＮＡ表达呈正相关（Ｐ＝０．００６４；Ｐ＝０．０４１９），且ｃ－ｆｏｓ与ｃ－ｅｒｂＢ－２共同阳性的病例ＰＣＮＡ标记率高。ｃ－ｆｏｓ与ｃ－ｅｒｂＢ－２表达呈正相关。结论：过表达的ｃ－ｅｒｂＢ－２激活后可以导致ｃ－ｆｏｓ的表达，两者都能促进卵巢癌细胞增殖，且有协同作用。ｃ－ｆｏｓ表达与卵巢癌低分化、易浸润、转移有关。ｃ－ｆｏｓ表达，尤其与ｃ－ｅｒｂＢ－２共同表达，可能标志卵巢癌中恶性程度较高的一种类型。
Objectives:To investigate the expression of cell growth regulating gene c fos and c erbB 2 in ovarian cancer and to discuss their roles in the development of ovarian cancer.Methods:38 cases of ovarian cancer were detected by immunohistochemical technique LSAB(labeled strept avidin biotin)method.Results:c fos was expressed in 66%(25/38)of ovarian cancer cases.c fos was more frequently expressed in poorly differentiated cases than that in well and moderatly differentiated ones.c fos expression also had a strong relationship with clinical stage: c fos was expressed in 45% and 89% of stage Ⅰ/Ⅱ and Ⅲ/Ⅳ cases respectively,the difference was statistically significant.Both c fos and c erbB 2 had positive relationships with PCNA expression.c fos and c erbB 2 expressions were correlated.Conclusions:When activated,the overexpressed c erbB 2 may induce c fos to overexpress,both of them can promote ovarian cancer cell to proliferate.c fos expression is related with poor differentiation and propensity to invade and to metastasize in ovarian cancer.c fos expression,especially coexpression with c erbB 2,may indicate a more aggressive type of ovarian cancer.To prevent the expression of such genes as c fos and c erbB 2 or to suppress their activity may be the new therapeutic method for ovarian cancer.
出处
《现代妇产科进展》
CSCD
1998年第2期140-142,共3页
Progress in Obstetrics and Gynecology
