摘要
目的探讨抑癌基因Survivin、Livin在非小细胞肺癌(NSCLC)中的表达及临床意义。方法采用免疫组化S-P法检测52例NSCLC癌组织、20例癌旁5 cm以上正常肺组织中Survivin、Livin蛋白表达情况。结果Sur-vivin、Livin蛋白在NSCLC组织中的表达水平明显高于癌旁肺组织(61.54%vs 5.00%,48.08%vs 0.00%,P<0.05);Survivin蛋白的表达与腺癌密切相关(P<0.05);Livin蛋白的表达与患者淋巴结转移密切相关(P<0.05);Survivin与Livin间(rs=0.193,P>0.05)无明显相关性。结论Survivin和Livin蛋白在非小细胞肺癌组织中表达上调;Survivin蛋白的表达与NSCLC患者组织类型密切相关;Livin蛋白的高表达可能与NSCLC癌细胞的转移有密切关;Survivin和Livin蛋白之间无明显相关性。
Objective To investigate the expression of Survivin and Livin of apoptosis inhibitors and it＇s clinical significance in non-small cell lung cancer （NSCLC）. Methods The expressions of Survivin and Livin were assessed by S-P immunohistochemical staining in postoperative samples from 52 patients with the diagnosis of non-small cell lung cancer as well as adjacent normal tissue than 5 cm. Results The expression level of Survivin and Livin was higher in NSCLC tissue samples than that in adjacent tissue samples（61. 54% vs 5.00%,48.08 vs 0.00%,P〈 0.05）. The expression level of Survivin was significantly associate with the adenocarcinoma（P〈 0.05） and expression level of livein was closely relate with lymph node metastasis in NSCLC（P〈 0.05）. The expression level of Survivin had no Significant correlation with that of Livin （rs= 0. 193,P〉0.05）. Conclusion The expression of Survivin and Livin is upregulated in NSCLC. Survivin protein expression is associate with histological types of NSCLC patients. High Livin protein expression might indicate the transfer of NSCLC. Survivin has no significant correlation with Livin protein.
出处
《江西医学院学报》
CAS
2009年第3期79-81,85,共4页
Acta Academiae Medicinae Jiangxi
