摘要
目的探讨BMSCs对消化道损伤的修复作用及其机制。方法查阅近年来关于BMSCs对消化道损伤修复作用的文献,并进行回顾和综合分析。结果BMSCs具有自我复制、增殖和多向分化潜能,在消化道损伤修复中作用重大。其可能作用机制为BMSCs能迁移至消化道损伤组织,抑制宿主免疫应答;去分化和再分化;直接分化为消化道上皮干细胞或消化道上皮细胞;与消化道上皮干细胞或成熟上皮细胞融合;参与损伤后微环境的重建。结论BMSCs参与消化道损伤修复,在消化系统疾病的治疗中具有广阔的应用前景。
Objective To investigate the effect of BMSCs on the repair of digestive tract injury and its mechanisms. Methods Recent literature on the effect of BMSCs on the repair of digestive tract injury was reviewed. Results BMSCs had the potency of self-replication, proliferation and multi potential differentiation, which played an important role in the repair of digestive tract iniury. The probable mechanisms included： BMSCs＇ ability of migrating to the injured tissue and inhibiting the host immune response; BMSCs＇ dedifferentiation and redifferentiation; BMSCs＇ direct differentiation into the epithelial cells or the stem cells of digestive tract; BMSCs＇ fusion with the stem cells or the mature epithelial cells of digestive tract; BMSCs＇ participation in the reconstruction of injured microenvironment. Conclusion BMSCs participates in the repair of digestive tract iniury and has a bright future in the treatment of digestive system disease.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2009年第6期751-754,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目(30672065)
教育部博士点基金资助项目(20070610146)
中国博士后科学基金资助项目(20080431262)~~
关键词
BMSCS
消化道损伤
修复重建
综述
BMSCs
Digestive tract injury
Repair and reconstruction
Review
