摘要
目的:观察四君子汤对早产儿胃肠功能成熟的促进作用。方法:将120例早产儿随机分为对照组和四君子汤组。对照组给予早产儿常规治疗,四君子汤组给予早产儿常规治疗+口服四君子汤;观察两组早产儿首次大便时间、大便转黄时间、胃潴留量;呕吐、腹胀、腹泻、NEC、高胆红素血症的发生率及胃管插管率;第10d体重增长情况;出生第1d及第7d测定胃动素(motilin,MOT)和胃泌素(gastrin,GAS)水平,并检测血糖及血胆红素水平。结果:两组早产儿首次排便时间、腹泻发生率差别无统计学意义(P>0.05),四君子汤组大便转黄时间较对照组明显缩短,呕吐、腹胀、胃潴留、NEC、高胆红素血症的发生率较低,差异有统计学意义(P<0.05);两组早产儿胃管插管率、10日龄体重增长比较差异有统计学意义(P<0.05)。7日龄血浆胃动素浓度显著高于对照组,差异有统计学意义(P<0.05),血浆胃泌素浓度亦高于对照组,但差异无统计学意义(P>0.05)。结论:四君子汤能使胃肠激素释放增加,促进早产儿胃肠道生长、发育及成熟,减轻早产儿黄疸程度,帮助早产儿度过喂养关,且未见明显不良反应,值得临床推广使用。
Objective： To observe the effect of Sijunzi decoction on gastrointestinal function of premature infants. Methods： One hundred and twenty premature infants were randomly divided into a treatment group （with routine treatment and oral Sijunzi decoction） and a control group （with routine treatment only）. Then the clinical symptoms, such as the time of meeonium and yellow-stool excreted, body weight on the 10th day, vomiting, abdominal distention, diarrhea, neonatal neerotizing enteroeolitis （NEC） and hyperbilirubinemia incidence and stomach tube rate of the two groups were observed after treatment. Blood sugar, blood bilirubin, plasma motilin and gastrin concentration of 120 premature infants on the 1 st day and the 7th day were tested. Results： There was no difference in the time of first dejection, diarrhea incidence of premature infants between the two groups （ P 〉 0.05 ）. The time of yellow-stool being excreted in the treatment group was shorter than in the control group （ P 〈 0.05 ）. There was significant difference in the body weight increase of 10-day-old, vomiting, abdominal distention, NEC and hyperbilirubinemia between the treatment group and the control group （ P 〈 0.05 ）. There was significant difference in stomach tube rate （ P 〈 0.05 ） but the plasma motilin concentration was significantly increased compared with the control group. The difference showed statistical significance （ P 〈 0.05 ）. The plasma gastrin concentration was increased compared with that of the control group, but without statistic significance （P 〉 0.05 ）. Conclusions： Sijunzi decoction can facilitate gastrointestinal hormone release, promote development and maturation of premature infants＇ gastrointestinal function, lighten bilirubin degree of premature infants, help the infants pass the feeding time with no obvious side-effect. So it is worth popularizing.
出处
《儿科药学杂志》
CAS
2009年第3期15-17,共3页
Journal of Pediatric Pharmacy
关键词
早产儿
四君子汤
胃肠功能
胃动素
胃泌素
Premature infant
Sijunzi decoction
Gastrointestinal function
Motilin
Gastrin
