摘要
目的:探讨阿托伐他汀联合氯吡格雷治疗急性脑梗死的临床疗效和预后。方法:120例急性脑梗死患者,随机分为阿托伐他汀联合氯吡格雷治疗组(60例)和单用氯吡格雷治疗组(60例),随访6个月,比较2组治疗前、后的美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力指数(BI)、改良的Rankin(mRS)评分和简易智能量表(MMSE)评分。结果:2组患者在治疗后3个月和6个月的NIHSS、BI和mRS评分均比治疗前有好转,差异均有显著性(P<0.05)。阿托伐他汀联合氯吡格雷治疗组在治疗后6个月时NIHSS、BI和mRS评分的好转优于单用氯吡格雷治疗组,且差异有显著性(P<0.05)。MMSE的变化无统计学意义。结论:阿托伐他汀联合氯吡格雷治疗有利于神经功能、日常生活能力的恢复,改善预后,可作为急性脑梗死治疗的联合药物。
OBJECTIVE To investigate the therapeutic efficacy of atorvastatin combined with clopidogrel on acute cerebral infarction and the improvement on the prognosis of the disease. METHODS 120 cases with acute cerebral infarction were randomly divided into two groups： 60 cases were treated with atorvastatin combined with clopidogrel; 60 cases were given clopidogrel only. The scores of NIHSS, Barthel, mRS and MMSE were estimated before and 3 and 6 months after treatment. RESULTS In these two groups, all of the scores of NIHSS, Barthel and mRS were improved 3 and 6 months after the therapy （P 〈0. 05）. The scores of NIHSS, Barthel and mRS were improved more in atorvastatin plus clopidogrel therapy group than those in clopidogrel therapy group. The significant statistical difference was found （P〈0. 05）. No alternation of MMSE estimation was found with no statistical difference（P〉0. 05）. CONCLUSION Atorvastatin plus clopidogrel therapy may be beneficial for restoring the nervous function and improving the ability of daily living and the prognosis. Atorvastatin plus elopidogrel can be used in acute cerebral infarction as a therapeutic approach.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第11期924-926,共3页
Chinese Journal of Hospital Pharmacy
关键词
阿托伐他汀
氯吡格雷
急性脑梗死
atorvastatin
clopidogrel
acute cerebral infarction
