摘要
目的探讨氟比洛芬酯复合小剂量曲马多与单纯曲马多术后静脉镇痛的临床效应。方法选取全髋关节置换术的患者80例,随机分为4组:Ⅰ组,曲马多600mg+0.9%生理盐水+昂丹司琼16mg;Ⅱ组,曲马多400mg+0.9%生理盐水+昂丹司琼16mg;Ⅲ组,氟比洛芬酯50mg+曲马多400mg+0.9%生理盐水+昂丹司琼16mg;Ⅳ组,氟比洛芬酯100mg+曲马多200mg+0.9%生理盐水+昂丹司琼16mg。每组总量均为100mL。镇痛模式:背景流量2mL/h,自控剂量0.5mL/次,锁定时间15min。观察24h内的镇痛评分(VAS),PCIA术后镇痛效果及不良反应的发生情况。结果术后1h时Ⅱ组的VAS显著高于Ⅰ,Ⅲ和Ⅳ组(P<0.05),而1h后的VAS4组间差异无显著性(P>0.05)。Ⅱ,Ⅲ和Ⅳ组恶心、呕吐的发生率显著低于Ⅰ组(P<0.05)。镇痛期间无呼吸抑制及异常出血等并发症发生。结论氟比洛芬酯复合曲马多术后静脉镇痛效果良好,可明显减少曲马多的用量和不良反应的发生率。
Objective To compare analgesic effect and complications of intravenous postoperative analgesia with flurbiprofen axeyil injetion combined with tramadol hydrochloride and with tramadol hydrochloride alone. Methods 80 cases of postoperative patients undergoing total hip arthroplasty were randomly divided into four groups with 20 cases each,tramadol hydrochloride 600mg Ⅰ group, tramadol hydrochloride 400mg Ⅱ group,flurbiprofen axeyil injection 50mg plus tramadol hydrochloride 400mg in group Ⅲ and flurbiprofen axeyil injection 100mg plus tramadol hydrochloride 200mg in group Ⅳ. The drugs in each group were diluted to 100ml. analgesic pattern：background flow rate 2mL/h,self-controlled dose 0.5ml every time,locking time 15min. The visual analog scale （VAS）,analgesic effect of PCIA and incidence of side effects were recorded during the period of postoperative 24 hours. Results The VAS of group Ⅱ at lh after operation was significantly higher than that of group Ⅰ , Ⅲ and Ⅳ（P〈0.05）, which became similar lh later（P 〉 0.05 ）. The accidences rate of nausea,vomiting in group Ⅱ , Ⅲ and Ⅳ were significantly less than those in group Ⅰ （P 〈 0.05）. No respiratory depression or abnormal bleeding occurred in four groups. Conclusion Intravenous postoperative analgesia with flurbiprofen axeyil injection combined with tramadol hydrochloride has a better analgesic effect than tramadol hydrochloride alone and can reduce tramadol hydrochloride requirement and its side effects.
出处
《中国现代医生》
2009年第16期100-101,110,共3页
China Modern Doctor
关键词
氟比洛芬酯
曲马多
术后静脉镇痛
Flurbipmfen Axeyil
Tramadol hydrochloride
Postoperative analgesia
