摘要
目的了解糖尿病足合并感染患者的病原菌分布与药敏状况。方法对2000年6月-2007年12月收治的102例糖尿病足感染患者的创面分泌物,进行病原菌培养和药敏结果分析。结果102例患者分泌物标本中70例患者(68.6%)培养出病原菌109株,其中革兰阳性菌61株,革兰阴性菌43株,真菌5株;单一菌感染37例,混合菌感染33例,其中Wagner分级≥3级糖尿病足者28例(84.85%),药敏试验结果提示多药交叉耐药,革兰阳性菌对万古霉素、氯霉素及头孢菌素较敏感;革兰阴性菌对亚胺培南及加β-内酰胺酶抑制剂的抗菌药物较为敏感。结论糖尿病足感染的病原菌分布广泛,对抗菌药物耐药率高,早期联合选择敏感抗菌药物治疗是糖尿病足感染治疗的关键。
OBJECTIVE To study the antimicrobial sensitivity of pathogens isolated from diabetic foot patients. METHODS Totally 102 diabetic foot patients were enrolled from Jun 2000 to Dec 2007 in our hospital. Specimens such as pus and wound exudate were collected for culture. Pathogenic spectrum and antimicrobial sensitivities were investigated. RESULTS From 70 cases 109 strains of pathogenic bacteria were isolated, of which 61 were Grampositive bacteria, 43 Gram-negative bacteria and 5 fungi. Thirty-seven patients were with single microbial infection and 33 patients with polymicrobial infection and 28 of 33 patients were with Wagner＇s grade 3 and upwards. According to susceptibility test, multi-drug resistance was found. Gram-negative bacteria were sensitive to imipenem and β-lactamases inhibitor, and Gram-positive bacteria were sensitive to vaneomycin, chloramphenicol, and cephalosporin. CONCLUSIONS The pathogenic bacteria in diabetic loot infection distribute extensively and some of them are multi-drug resistant. The key to the treatment of diabetic foot infection is early combination application of sensitive antimierobial agents.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第11期1458-1460,共3页
Chinese Journal of Nosocomiology
关键词
糖尿病足
感染
病原菌
药物敏感性试验
Diabetic foot
Infection
Pathogenic bacteria
Antimicrobial sensitivity test
