摘要
近年来,一些大规模临床研究显示,激素替代治疗无益于女性冠状动脉性心脏病预防。然而深入分析现有资料,可以发现雌性激素替代治疗的心血管保护作用与患者年龄以及开始治疗的时机和治疗持续时间密切相关。长期雌性激素治疗可以降低较年轻的围绝经期女性人群的总病死率和冠状动脉性心脏病风险,并且治疗相关性风险并不高于冠状动脉性心脏病的其他一级预防措施。
Within the last decade, several large clinical studies have suggested that hormone replacement therapy fails to prevent coronary heart disease in women. However, peer sub-group analysis showed that cardio-proteetion of hormone replacement therapy is closely associated with the age of a patient, timing of therapy initiation, and the duration of treatment. Long-term hormone replacement therapy might reduce the risk of coronary heart disease when initiated in young postmenopausal women, when used in close proximity to menopause. Moreover, the risks of therapy are rare and of the same magnitude as other primary prevention therapies for coronary heart disease.
出处
《心血管病学进展》
CAS
2009年第3期446-448,共3页
Advances in Cardiovascular Diseases
关键词
激素替代治疗
冠状动脉性心脏病
女性
绝经期
hormone replacement therapy
coronary heart disease
female
peri-menopause
