摘要
目的分析趋化因子受体CXCR4在乳腺癌中的表达及其与乳腺癌临床病理特征的关系,探讨CXCR4在乳腺癌发病中的作用。方法应用免疫组织化学方法检测46例乳腺癌组织、30例乳腺癌旁组织和30例正常乳腺组织中CXCR4的表达,分析其不同表达与患者年龄、肿瘤大小、雌激素受体(ER)、孕激素受体(PR)、TNM分期、病理分级和淋巴结转移等临床特征的关系。结果46例乳腺癌组织中CXCR4的表达率为61%,显著高于正常乳腺组织和乳腺癌旁组织,差异有高度统计学意义(P<0.01)。乳腺癌组织中CXCR4的高表达与TNM分期、病理分级和淋巴结转移相关(均P<0.05)。结论CXCR4在乳腺癌中有较高的表达率,其可能在协同促进乳腺癌的侵袭转移中起重要作用。
Objective To investigate the expression of chemokine receptor CXCR4 in breast cancer and its relationship to the clinicopathological features of breast cancer. Methods Expression of CXCR4 was evaluated by immunohistochemical study in 46 breast cancer specimens, 30 paraeancerous specimens and 30 normal breast specimens. The relation between the staining expression and ＇elinicopathological features including age, tumor size, estrogen receptor （ER）, progesterone receptor （PR）, TMN stage, pathological grade, and lymph node metastasis was examined. Results The high expression rate of CXCR4 in 46 breast cancer specimens was 61%. The lever of CXCR4 expression was significantly higher in the breast cancer than that in the normal breast and paracaneerous tissues （P〈0.01）. High expression of CXCR4 was correlated significantly with TNM stage, pathological grade, and lymph node metastasis （P〈0.05）. Conclusion CXCR4 is expressed in the breast cancer at a high frequency. The high expression of CXCR4 may play an important role in invasion and metastasis of breast cancer.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2009年第2期321-323,394,共4页
Suzhou University Journal of Medical Science
