摘要
目的评价非洛地平、氨氯地平、硝苯地平等长效制剂的降压效果、持续时间。方法120例符合1999年WHO/ISH诊断标准门诊高血压患者随机分成3组,分别给予口服非洛地平缓释片10mg,1次/d;氨氯地平5mg,1次/d;硝苯地平控释片30mg,1次/d;4周为1疗程,观察其降压效果。结果3组病例服药后血压均显著下降,非洛地平缓释片组由治疗前的(21.4±1.64)/(13.29±0.69)kPa下降到(19.8±1.32)/(11.45±0.59)kPa;氨氯地平片组由治疗前的(22.85±1.54)/(13.9±1.34)kPa下降至(18.4±0.65)/(10.4±0.85)kPa;硝苯地平控释片组治疗前的(22.75±1.53)/(13.87±1.36)kPa下降至(18.3±0.79)/(10.8±0.79)kPa。结论从治疗效果比较,3组患者通过4周治疗后血压下降平稳,且能在24h维持在有效血药浓度范围内,无"突释"现象所致的头痛、面红、头晕、心率增快等副反应,也无"延迟释放"现象造成血压骤升,是理想降压药。
Objective To evaluate the depressurization effect and persistence time of felodipine, amlodipine and nifedipine. Methods 120 hypertension patients who consist with the diagnostic criteria of WHO/ ISH of 1999 in out-patient clinic were classified into 3 groups. They were treated with oral Felodipine Sustaindrelease Tablets（ 10 mg/day）, amlodipine （ 5 mg/day）, and Nifedipine （ 30 mg/day） individually. 4 weeks is one course of treatment, and then observe the depressurization effect. Results There is remarkable descent of blood pressure in all three groups. The blood pressure of Felodipine Sustaind-release Tablets group descend from （21.4 ± 1.64）/（ 13.29 ±0. 69） kPa to （ 19. 8 ± 1.32）/（ 11.45 ± 0. 59 ） kPa; the amlodipine group descend from（22. 85 ± 1.54）/（ 13.9 ±1.34） kPa to （ 18.4 ±0. 65）/（ 10.4 ±0. 85） kPa;and the Nifedipine group descend from（22.75±1.53）/（13.87±1.36） kPa to （18. 3 ±0. 79）/（10. 8 ±0. 79） kPa. Conelusion Inrespect to the therapeutic efficacy, the blood pressure descended steadily after 4 weeks treatment in all 3 groups. The effective blood drug level can be persisted for 24 hours. There is no adverse reactions caused by ＂suddenly release ＂ such as headache, flushing, dizziness, Increased heart rate and so on. Also there is no suddenly ascending of blood pressure caused by ＂ delayed release ＂. They are the ideal hypotensive drugs.
出处
《中国现代药物应用》
2009年第12期31-32,共2页
Chinese Journal of Modern Drug Application
