摘要
莱姆病是一种虫媒传染病,其病原体是伯氏疏螺旋体。莱姆病主要表现为皮肤游走性红斑、复发性关节炎、心脏传导障碍和神经系统损害。其中,莱姆关节炎发生率和致残率高,危害最大。莱姆关节炎的发病机制尚不完全清楚,主要原因可能是螺旋体脂蛋白在感染早期引起机体固有免疫应答,随后引起适应性免疫应答,从而造成关节的炎症和损伤。本文对近年有关莱姆关节炎的研究进展进行简要总结,并介绍了作者在莱姆关节炎研究中的一些重要发现。
Lyme disease is an arthropod-borne infectious disease, whose hallmarks are erythema migrans （EM）, episodes of arthritis, disruption of electrical conduction of cardiac muscle, and the development of neurological abnormalities. Some of these clinical features, especially arthritis, subside and recur throughout the course of infection. Arthritis is a leading cause of Lyme disease-associated morbidity, affecting approximately 60% of individuals infected with B. burg-dorferi. Intermittent episodes of arthritis develop several weeks or months after infection. The highly inflammatory aspects of Lyme arthritis can lead to cartilage and bone erosion with permanent joint dysfunction. The mechanism（s） by which B. burgdorferi interacts with the host immune system to induce arthritis is not fully understood. Initially, effectors of the innate immune system play a significant role in the induction of Lyme arthritis. Afterwards, a variety of host mechanisms work together to initiate an adaptive immune response to the organisms and induce a strong inflammation process in the joints. A synopsis of data from studies of Borrelia-infected humans and animals of currently known mechanisms responsible for the induction of Lyme arthritis following infection with B. burgdorferi was introduced.
出处
《中国病原生物学杂志》
CSCD
2009年第5期380-382,386,共4页
Journal of Pathogen Biology
基金
云南省自然科学基金项目(No.2007C069M)。
