摘要
目的为临床准确评估ＧＦＲ提供一定依据。方法我们对３２例慢性肾脏病患者及５例正常志愿者，用９９ｍＴｃ－ＤＴＰＡ的清除率测定肾小球滤过率（Ｔｃ－ＧＦＲ），同时测定血尿素氮（ＢＵＮ），肌酐（Ｓｃｒ），２４小时肌酐清除率（２４ｈＣｃｒ）和采用Ｃｏｃｋｃｒｏｆｔ－Ｇａｕｌｔ公式计算肌酐清除率（Ｃｃｏｃｋｃｒｏｆｔ），并进行比较和分析。结果以上指标与Ｔｃ－ＧＦＲ均存在相关关系；它们检出Ｔｃ－ＧＦＲ下降的敏感性分别是５０％、５８％、６９％和８０％；２４ｈＣｃｒ和Ｃｃｏｃｋｃｒｏｆｔ与Ｔｃ－ＧＦＲ的相关性显著优于ＢＵＮ，Ｃｃｏｃｋｃｒｏｆｔ检出Ｔｃ－ＧＦＲ下降的敏感性显著优于ＢＵＮ。结论传统的指标除ＢＵＮ外均能一定程度地准确反映ＧＦＲ。９９ｍＴｃ－ＤＴＰＡ清除率可以准确，安全，有效地测定ＧＦＲ，适用于某些对ＧＦＲ精确性要求较高的情况。
Objective To determine adequate measurement of glomerular filtration rate(GFR) in clinicalMethods We measured GFR in 32 patients with chronic renal disease and 5 normal subjects using urinary clearance of ^(99m) TcDTPA (TcGFR)Blood urea nitrogen (BUN),serum creatinine(Scr) and 24hour creatinine clearance (24hCcr) were determined simultaneouslyGreatinine clearance also estimated from CockcroftGault formula (Ccockcroft)Then we carried out comparison and analysisResults BUN,Scr,24hCcr and Ccockcroft were all correlated with GFR significantly,sensitivities in detecting a reduced GFR were 50%,58%,69% and 80% respectively24hCcr and Ccockcroft were more closely correlated with GFR than BUN,sensitivity of Ccockcroft in detecting a reduced GFR was higher than BUNConclusion The traditional indexes except BUN could provide an adequate estimate of GFR in some degreeUrinary clearance of ^(99m) Tc DTPA provided an accurate,safe and effective measurement of GFR,not only in clinical trials,but in some practical settings where more accurate and sensitive estimates of GFR were required
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1998年第3期177-180,共4页
Chinese Journal of Nephrology
关键词
肾小球滤过率
锝99M
DTPA
清除率
肾疾病
Glomerular filtration rate Clearance of ^(99m) TcDTPA Blood urea nitrogen Creatinine clearance
