摘要
目的研究达英-35与二甲双胍对多囊卵巢综合征(PCOS)患者激素水平及卵巢状态的影响。方法选择PCOS患者90例,随机分为对照、达英-35和联用三组。达英-35组接受达英-35单独治疗,联用组接受二甲双胍及达英-35治疗,连续3个月,治疗前后分别测定黄体生成素(LH)、促卵泡素(FSH)、雌二醇(E2)、睾酮(T)。测量每侧卵巢内卵泡数目、卵巢体积。结果经治疗3个周期后,达英-35组的E2、LH、LH/FSH和T均显著低于对照组(P<0.05),但FSH下降不明显(P>0.05);而联用组E2、LH、FSH、LH/FSH和T均较对照组显著改善(P<0.05);联用组与达英-35组比较,仅FSH间的差异有统计学意义(P<0.05)。联用组双侧卵巢体积较治疗前明显缩小,卵泡数目也明显减少,与服药前相比均有显著性差异(P<0.01)。两治疗组未出现严重不良反应。结论二甲双胍与达英-35合并用于PCOS患者能改善PCOS患者内分泌水平,显著改善卵巢状态。
Objective To investigate the effect of hormone levels and ovarian situation with the treatment of ECAT and mefformin in PCOS. Methods Ninty patients with PCOS were divided into three groups：control,ECAT and united. The ECAT group was just treated with ECAT. The united group was treated with metformin besides ECAT. Their LH,FSH,E2,T,Bilateral ovarian volume and follicle numbers were measured after three months treatment. Results E2,LH,LH/FSH and T of the ECAT group were significant lower than that of the control group,but there was no significant difference of FSH between them. The hormone level of the united group was changed significantly,But there was no significant between the ECAT group and the united group except FSH. Bilateral ovarian volume and follicle numbers were changed significantly after treatment in the united group. Conclusion The hormone level and ovarian situation can be improved of the patients of PCOS by united treatment of ECAT and mefformin.
出处
《中国现代医生》
2009年第18期6-7,40,共3页
China Modern Doctor
关键词
达英-35
二甲双胍
多囊卵巢综合征
Ethinylestradiol and Cyproterone Acetate Tablets（ECAT）
Metformin
PCOS
