摘要
目的:研究早产儿颅内出血(Intracranial hemorrhage,ICH)的高危因素,探讨有利于ICH防治的策略。方法:选择横沥医院2006年1月～2008年12月57例早产儿ICH作为研究组,同期79例非ICH的早产儿作为对照组,对19个高危因素进行分析。结果:早产儿ICH发病率为41.9%。单因素分析发现胎龄、出生体重、妊高征、窒息、产伤、滞产、脐带绕颈、宫内窘迫、呼吸暂停、代谢性酸中毒、机械通气、吸入高浓度氧、产前应用地塞米松与早产儿ICH有关(P<0.05)。Logistic回归分析确定胎龄、出生体重、窒息、宫内窘迫、呼吸暂停、代谢性酸中毒、机械通气、产前应用地塞米松为早产儿ICH影响因素(P<0.05)。结论:早产儿ICH的高危因素众多,其发病机制复杂,是外部医疗环境与患者本身内环境因素综合作用的结果,采取综合防治措施可能是控制早产儿ICH的最佳策略。
Objective： To observe the high risk factors of intracranial hemorrhage in premature infants, explore preventive and therapeutic strategies. Methods： 57 premature infants with intracranial hemorrhage and 79 premature infants without intracranial hemorrhage were selected as study group and control group from January 2006 to December 2008. 19 high risk factors were analyzed. Results ： The incidence of intracranial hemorrhage was 41.9%. Univariate analysis showed that gestational age, birth weight, hypertensive disorder complicating pregnancy, asphyxia, birth injury, prolonged labor, cord around neck, fetal distress, apnea, metabolic acidosis, mechanieal ventilation, high density O2 inhalation and antepartum dexamethasone treatment were related to intracranial hemorrhage of premature infants （ P 〈 0.05 ） . Logistic regression analysis showed that gestational age, birth weight, asphyxia, fetal distress, apnea, metabolic acidosis, mechanical ventilation and antepartum dexamethasone treatment were effect factors of intracranial hemorrhage （ P 〈 0. 05 ） . Conclusion ： The risk factors of intracranial hemorrhage in premature infants is multifactorial, including external medical environments and patients, internal agents, comprehensive measures maybe the optimal strategy to control intracranial hemorrhage in premature infants.
出处
《中国妇幼保健》
CAS
北大核心
2009年第19期2655-2657,共3页
Maternal and Child Health Care of China
关键词
婴儿
早产
颅内出血
高危因素
Infant
Premature birth
Intracranial hemorrhage
High risk factors
