摘要
用乳化聚合法制备丹酚酸B-聚氰基丙烯酸正丁酯纳米粒(Sal B-PBCA NP),以吐温80和PEG 20000制备了Sal B-PBCA NP的两种包衣产物T1P0、T1P1,并考察其体外释药特性。结果表明:Sal B-PBCA NP纳米粒平均粒径99.2 nm,包封率为46.55%,载药量0.792%;Sal B-PBCA NP、T1P0、T1P1在48 h后分别累积释放(76.15±0.69)%、(63.72±1.80)%、(47.09±5.72)%;体外释药结果均符合Weibull方程。与未包衣的Sal B-PBCA NP相比,以吐温80和PEG 20000包衣的T1P1具有明显的缓释作用。
Salvianolic acid B poly （butylcyanoacrylate） nanoparticles （Sal B-PBCA NP） were prepared by emulsion polymerization method. Two formulations, T1P0 and T1P1, were prepared by coating surface of Sal B-PBCA NP using Tween 80 and PEG 20000. Drug release profiles from different formulations of Sal B PBCA-NP, T1P0, T1P1 were determined. Results indicate that mean diameter, entrapment efficiency and drug loading of Sal B-PBCA NP were 99.02 nm, 46.55% and 0. 792%, respectively. It was found that the in vitro release of Sal B-PBCA NP, TIP0 and TIP1 were accumulated up to （76.15±0.69）%, （63.72± 1.80）% and （47.09±5.72）% over 48 h, respectively. The in vitro release properties could be expressed by the Weibull equation. Compared with Sal B-PBCA NP without surface coating, formulation T1P1 obtained by coating surface of Sal B-PBCA NP using Tween 80 and PEG 20000 showed significant sustained release effect.
出处
《华东理工大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第3期411-415,共5页
Journal of East China University of Science and Technology
关键词
丹酚酸B
纳米粒
体外评价
氰基丙烯酸正丁酯
salvianolic acid B
nanoparticles
in vitro evaluation
butylcyanoacrylate
