摘要
目的研究胸腺肽对严重烧伤患者的免疫调理作用。方法选取30例严重烧伤患者(其中15例除常规治疗外还应用胸腺肽治疗),分别于伤后3、7、14、28天抽取静脉血,酶联免疫吸附实验(ELISA)法测定肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ),并用流式细胞仪测定单核细胞表面人类白细胞DR抗原(HLA-DR)。结果接受胸腺肽治疗的患者血浆IFN-γ水平升高持续至停药后较长的一段时间,未接受胸腺肽治疗的患者IFN-γ水平几乎测不出。接受胸腺肽治疗的患者与未接受胸腺肽治疗的患者外周血TNF-α水平无显著差异。伤后7、14、28天接受胸腺肽治疗的患者单核细胞HLA-DR较未接受治疗组高。结论胸腺肽对严重烧伤患者的免疫功能有明显改善。
Objective To study the immune opsonization of thymic peptide in severe burned patients. Methods The peripheral blood was drawn from 30 severe burned patients （ 15 of them were given 1.6mg thymic peptide every other day） on days 3,7,14,28 after injury. TNF-α and IFN-7 were measured by means of ELISA. The expressed HLA-DR of monocyte was measured by means of flow cytometry. Results The IFN-7 of the patients who were given thymic peptide increased,which was not found in control group. The TNF-α of the two groups had no significant difference. The HLA-DR in thymic peptide group was higher than that in control group. Conclusion Thymic peptide can largely improve the immune function of severe patients.
出处
《创伤外科杂志》
2009年第4期345-347,共3页
Journal of Traumatic Surgery
关键词
胸腺肽
免疫抑制
抗原
thymic peptide
immune inhibition
antigen
