摘要
目的观察NAHA方案治疗高血压的疗效及其对血液流变学的影响。方法选择486例高血压患者,随机分成治疗组和对照组各243例。对照组采用NAH方案,治疗组在NAH方案的基础上加用阿司匹林肠溶片75mg,每天一次,疗程均为18个月。两组患者治疗前及治疗4、8、12个月抽血查血液黏度,并检查血脂、肾功能、心电图,同时记录降压效果、不良反应的发生情况。结果两组患者临床疗效间差异无统计学意义(P>0.05)。两组患者治疗前全血黏度高切、低切、血浆黏度间差异无统计学意义(P>0.05),而治疗后两组患者全血黏度高切、低切、血浆黏度间差异有统计学意义(P<0.01)。结论使用小剂量阿司匹林可以改善高血压患者的血液流变学,从而对高血压的治疗及并发症的预防都起到积极的作用。
Objective To observe the effect of NAHA program on hypertension and its changes in blood theology. Methods Four hundred eighty - six hypertensive patients were divided randomly into groups treatment and control, 243 in each. Controls were given NAH treatment program, while treatment group additional aspirin enteric - coated tablets （75mg, once/d）, both lasted 18 months. Blood viscosity （BV）, blood lipids, renal function were determined and electrocardiogram, antihypertensive effect, adverse reactions were observed. Results There was significant difference in blood theology changes between 2 groups （ P 〈 0. 01 ）, but there was not in antihypertensive effect. Conclusion Use of small amount of aspirin can improve the increased blood rheology changes to play an active role in hypertension treatment and complication prevention.
出处
《实用心脑肺血管病杂志》
2009年第6期453-454,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
