摘要
目的:研究阿奇霉素与头孢噻肟对30株临床分离大肠杆菌的联合抗菌效应。方法:采用棋盘法设计,微量肉汤稀释法测定。测定不同浓度组合的2种抗菌药物对30株大肠杆菌的最低抑菌浓度,并计算FIC指数,以及观察两药不同加药顺序对效应的影响。结果:阿奇霉素与头孢噻肟联合应用后对大肠杆菌的浓度累积抑菌百分率曲线均比单独应用明显左移。FIC指数结果表明:阿奇霉素与头孢噻肟联合应用后对大肠杆菌17%为协同作用,60%相加作用,10%无关作用,13%拮抗作用;且拮抗作用均表现为于阿奇霉素或头孢噻肟的低于MIC的个别较低浓度处发生,而其他浓度处则仍表现为协同或相加作用。先后联用与同时应用抗菌效应差异无显著性(P>0.05)。结论:一般情况下,对临床分离大肠杆菌,阿奇霉素与头孢噻肟联合应用是合理的。
OBJECTIVE To evaluate the antibacterial effect of azithromycin combined with cefotaxime against 30 strains of E. coli from clinical specimens. METHODS The protocol was designed by checkerboard method and the MICs of azithromycin combined with cefotaxime or alone respectively against 30 strains of E. eoli were determined by broth dilution method, the FIC indexes were calculated according to MIC results. The antibiotic effects of the two drugs used at different time were observed. RESULTS The accumulative curve that of azithromycin combined with cefotaxime against E. coli moved to left more signifi cantly than that of azithromycin or cefotaxime alone against E. coli. From the FIC indexes, the percentage of the synergistic ac tion, additive effect, irrelevant action and antagonistic action of azithromycin combined with cefotaxime against E. coli was 17%, 60%, 10% ,13% respectively; and antagonistic action occurred in a few lower s of below MIC of azithromyein or cefotaxime only. There was no marked difference in antibacterial effect difference between the two administrations of azithromycin and cefotaxime at the same or different time（P〉0. 05）. CONCLUSION In general, it is to use azithromycin together with ce fotaxime against E. coli from clinical specimens.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第13期1088-1090,共3页
Chinese Journal of Hospital Pharmacy
基金
常州四药临床药学科研基金(编号:CS2007932)
