摘要
目的研究血清S-100B蛋白在诊断颅内恶性肿瘤放疗引起放射性脑损伤的临床价值。方法采用酶联免疫吸附测定法检测56例颅内恶性肿瘤患者放疗前、中、后血清S-100B蛋白水平，利用配伍设计的方差分析比较其差异。同时比较颅内恶性肿瘤患者不同放疗方案、瘤周水肿程度和卡氏评分对血清S-100B蛋白水平的影响。结果放疗前正常对照与放疗组分别（0．039±0．016）、（O．044±0．012）μg/L（t=1．48，P=0．186）。放疗前、中、后血清S-100B蛋白水平分别为0．044、0．049、0．079μg/L（F=67．26，P=0．000）。3种放疗方案（F=20．32，P=0．000）、瘤周水肿程度（F=12．94，P=0．000）和卡氏评分（t=2．71，P=0．007）对放疗后血清S-100B蛋白水平有影响。结论颅内恶性肿瘤放疗可导致血清S-100B蛋白水平升高且与放疗疗程（剂量）、放疗方案、瘤周水肿程度和卡氏评分相关，血清S-100B蛋白可作为诊断颅内恶性肿瘤放疗引起放射性脑损伤的较早指标。
Objective To study the value of serum S-100B protein in the diagnosis of cerebral radiation injuries in patients with brain malignant tumor. Methods Serum S-100B protein level was detected by enzyme-linked immunosorbent assay in 56 patients with brain malignant tumor before, during and after radiotherapy. Effects of dose and method of radiotherapy, peritumoral edema degree and Karnofsky performance status on serum S-100B level were studied. Results The levels of serum S-100B protein in the patients be- fore radiotherapy and control group were 0. 039 μg/L and 0. 044 μg/L （ t = 1.48, P = 0.186 ）. The levels of serum S-100B protein before, in the middle of （30 -40 Gy） and after （60 -70 Gy） radiotherapy were 0. 044 μg/L 0. 049 p,g/L and 0. 079μg/L respectively （ F = 67.26, P = 0.000 ）. The differences after ra- diotherapy were also significant among patients with three methods of radiotherapy （F = 20.32 ,P = 0. 000） , different degree of peritumoral edema （F = 12.94 ,P =0.000） and Karnofsky performance status （t = 2.71, P ： 0. 007 ）. Conclusions High level of serum S-100B protein is associated with cerebral radiation injuries in patients with brain malignant tumor, which is influenced by the dose and method of radiotherapy, Karnof- sky performance status and degree of peritumoral edema. High level of serum S-100B protein may serve as an early predictor of cerebral radiation injury.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2009年第4期312-315,共4页
Chinese Journal of Radiation Oncology
基金
山西省科技攻关项目（2006031090-03）
