摘要
实验观察生甘草和白鲜皮的两种乙醇提取物对小鼠药物性腹泻、实验性胃溃疡、胃肠推进运动和大鼠胆汁流量的影响。实验结果表明生甘草对小鼠蓖麻油性腹泻有较弱抑制作用，6g／kg生甘草明显抑制小鼠水浸应激性溃疡和盐酸性溃疡，1．2g／kg生甘草明显增加大鼠胆汁流量。白鲜皮对小鼠蓖麻油性腹泻也有较弱抑制作用，4g／kg白鲜皮明显抑制小鼠番泻叶性腹泻，4g／kg、12g／kg白鲜皮明显抑制水浸应激性溃疡，12g／kg白鲜皮明显抑制盐酸性溃疡和吲哚美辛-乙醇性溃疡，2．4g／kg、8g／kg白鲜皮明显增加大鼠胆汁流量。实验结果提示生甘草和白鲜皮对实验动物消化系统有明显保护和促进作用。
We observed pharmacological effects of two ethanol extracts of Glycyrrhizauralensis and Dictamnus dasycarpus on medicine-caused diarrhea, experimental gastric ulcer,gastroenteric propellent movement in mice and choleresis amount in rats The resalts showed thatGlycyrrhiza uralensis had weak inhibition effect on Castor oil-induced diarrhea in mice. The doseof 6 g/kg markedly inhibited the water-immersed stress-ulcer, HCI-induced gastric ulcer,and thedose of 1. 2 g/kg obviously increased choleretic amount in rats. Dictamnus dasycarpus had weakinhibition effect on Castor oil-caused diarrhea. The dose of 4 g/kg markedly inhibited Cassiaangustifolia leaf-diarrhea in mice. The dose of 4 g/kg, 12 g/kg markedly inhibited water-immersedstress-ulcer. The dose of 12 g/kg markedly inhibited HCI-ulcer and indomethacin-ethanol-ulcer.The dose of 2. 4 g/kg,8 g/kg significantly increased choleresis in rats. The results indicated thatGlycyrrhiza uralensis and Dictamnus dasycarpus have protective and promotive effects ondigestive system of experimental animal.
基金
国家自然科学基金!39370838
关键词
生甘草
白鲜皮
抗腹泻
抗溃疡
利胆
药理
Glycyrrhiza uralensis, Dictamnus dasycarpus, antidiarrhea, antiulcer,choleresis
