摘要
目的观察放疗联合唑来膦酸治疗骨转移癌疼痛的疗效及不良反应。方法60例骨转移癌患者随机分为3组,放疗联合唑来膦酸组(A组)、单纯放疗组(B组)、单纯唑来膦酸组(C组)各20例,观察比较各组疗效。结果A、B、C组疼痛缓解有效率分别为85%、80%和35%,A组与C组之间差异有显著性(P<0.05);随访2月后A、B、C组疼痛缓解有效率分别为80%、60%和25%,A组与C组之间差异有显著性(P<0.05);未发现严重放射及药物毒性。结论放疗联合唑来膦酸治疗骨转移癌疼痛的疗效优于单纯放疗或单纯唑来膦酸治疗,未见严重不良反应。
Objective To observe the therapeutic effects of radiotherapy combined with zoledronic acid in the treatment of osseous metastatic cancer. Methods 60 cases with osseous metastatic cancer were randomly divided into 3 groups： group A （radiotherapy combined with zoledronic acid group）, group B （radiotherapy group）, and group C （zoledronic acid group） with 20 cases in each group. The therapeutic effects were compared. Results The effective rates of painrelief in group A, B and C were 85%, 80% and 35% respectively, and there was a significant difference between group A and C （P 〈0.05）. The effective rates of pain-relief in group A, B and C became 80%, 60% and 25% respectively after followed-up for 2 months, and there was a significant difference between group A and C （P 〈0.05）. No serious radiation and drug toxicity was found. Conclusion Radiotherapy combined with zoledronic acid is superior to radiotherapy or zoledronic acid alone in the treatment of osseous metastatic cancer with no serious adverse reactions.
出处
《兰州大学学报（医学版）》
CAS
2009年第3期64-67,共4页
Journal of Lanzhou University（Medical Sciences）
关键词
放射治疗
唑来膦酸
骨转移癌
疼痛
radiotherapy
zoledronic acid
osseous metastatic cancer
pain
