摘要
目的总结并探讨原位肝移植术后新发肿瘤的发病特点、危险因素和防治措施。方法回顾性研究2002年4月～2008年4B间3例肝移植术后新发肿瘤患者的临床资料，并进行文献复习。结果本组资料新发肿瘤的发生率为0.3％，3例均为消化系统肿瘤（分别为肝细胞肝癌、食管癌和胰腺癌）。发病年龄平均52．7岁，肿瘤确诊时间平均为术后24个月。3例患者均死于肿瘤进展、多器官功能衰竭。结论肝移植术后新发肿瘤的发生率较高，消化系统肿瘤常见，确诊时间较晚，免疫功能低下是移植术后发生新发肿瘤的主要原因。
Objective To analyze the clinical characteristics, risk factors, prevention, and treatments of de novo neoplasms after orthotopic liver transplantation （OLT）. Methods The clinical data of 3 patients with de novo neoplasms out of the 1011 patients undergoing OLT during the period of 6 years （April 2002-April 2008） were analyzed. Results The morbidity of de novo neoplasms was 0.3%. The 3 neoplasms occurred in the gastrointestinal tract： being hepatic cellular cancer, esophageal cancer, and pancreatic cancer respectively with a mean diagnosis time of 24 months after the OLT. The mean age of onset was 52.7. All of the 3 patients died of tumor progression and multiple organ failure. Conclusion The incidence of de no neoplasm after OLT is high, most of which are digestive tumors. These malignancies are often diagnosed late. Immune deficiency is the primary etiological factor.
出处
《中国急救复苏与灾害医学杂志》
2009年第7期484-486,共3页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
肝移植
新发肿瘤
消化系统
Liver transplantation
De novo neoplasms
Digestive system
