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重组腺相关病毒载体在基因治疗中的应用 被引量：4

Application of Recombinant Adeno-Associated Virus in Gene Therapy
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摘要 重组腺相关病毒(rAAV)载体具有安全性好、免疫原性低、能感染分裂细胞和非分裂细胞、能介导基因长期稳定表达等优点。因此,作为一种基因导入系统,rAAV载体在基因治疗的研究和开发中越来越受到关注。本文就rAAV载体在基因治疗中的应用作一综述。 Recombinant adeno-associated virus （rAAV） has good safety and low immunogenicity, which may infect both divided and undivided cells and mediate the long-term and stable gene expression. As a gene delivery system, rAAV is paid more and more attentions in study on gene therapy. The application of rAAV in gene therapy is reviewed in this paper.
作者 董晓宇 井申荣
机构地区 昆明理工大学生物工程技术中心
出处 《中国生物制品学杂志》 CAS CSCD 2009年第7期734-736,共3页 Chinese Journal of Biologicals
基金 国家自然科学基金项目(30872398) 863计划重大项目(2006AA02A227) 云南省应用基础研究项目(2007C032M)
关键词 重组腺相关病毒 载体 基因治疗 Recombinant adeno-associated virus （rAAV） Vector Gene therapy
分类号 R394.8 [医药卫生—医学遗传学]
  • 相关文献

参考文献30

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二级参考文献13

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共引文献1

同被引文献20

  • 1李国强,刘仕勇,周政,陈军花.慢性颞叶癫痫模型鼠海马结构形态学的变化[J].第三军医大学学报,2007,29(2):125-128. 被引量：7
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引证文献4

二级引证文献11

中国生物制品学杂志
2009年 第7期

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