摘要
用对氯苯甲醛和对羧基苯甲醛为原料,合成了周边含羧基苯基的不对称卟啉中间体,然后再与5-氟尿嘧啶反应,合成了两种亚烷基链长不同的标题化合物,产率为22.1%和19.8%。产物结构由元素分析、红外光谱、紫外可见光谱、核磁共振谱和质谱表征确认。同时对目标化合物的合成条件进行了研究,结果表明,在以DMF为溶剂、反应温度在125℃、反应时间8h条件下,反应产率较高。
Using p-chlorobenzaldehyde and p-carboxylbenzaldehyde as the starting materials, the porphyrin intermediate containing carboxyphenyl in peripheral was synthesized, then it was reacted with 5-fluorouracil, the titled compounds with different alkylene length were synthesized with yields 22.1% and 19.8%, respectively. The structures of the products were characterized by elemental analysis, UV-Vis, IR, ^1 H NMR and MS. The results showed that the yield was higher when DMF was used as the solvent at 125℃ for 8h.
出处
《化学通报》
CAS
CSCD
北大核心
2009年第7期669-672,共4页
Chemistry
基金
河北省自然科学基金项目(203147)
国家自然科学基金项目(20601007)资助
关键词
卟啉
5-氟尿嘧啶
合成
表征
Porphyrin, 5-Fluorouraeil, Synthesis, Characterization
