摘要
目的:探讨单项及联合检测肿瘤标志物癌胚抗原(CEA)与糖类抗原199(CA199)在结直肠癌患者手术前后的表达及临床意义。方法:利用化学发光免疫方法检测70例结直肠癌患者术前及术后化疗3个月血清CEA和CA199水平,分析CEA和CA199检测值与结直肠癌的诊断及术后化疗临床特征之间的关系。结果:结直肠癌患者术前血清CEA和CA199水平显著高于术后化疗与健康对照组(P<0.05),手术后,经过3个月的化疗,结直肠癌患者的CEA和CA199水平与正常健康人无显著性差异(P>0.05),联合检测既可以提高对结直肠癌诊断的阳性率,又可以对术后化疗的效果进行评价。结论:血清CEA和CA199联合检测可用于结直肠癌的辅助诊断以及预后的判断。
Objective： To study the preoperative and postoperative expression and the clinical significance of carcinoem- bryonic antigen （CEA）, carbohydrate antigen （CA199） and combined detection of colorectal carcinoma. Methods： The preoperative and 3 months postoperative changes of CEA and CA199 of 70 cases of patients with colorectal carcinoma were evaluated by chemiluminescence immunoassay, and the relationship between the diagnosis and postoperative chemotherapy clinical characteristics of colorectal carcinoma was analyzed. Results： The values of CEA and CA199 in patients with colorectal carcinoma in preoperation were higher than the patients underwent postoperative chemotherapy and the healthy individuals （P〈0.05）. After received chemotherapy for 3 months, the levels of CEA and CA199 of patients with colorectal carcinoma showed no difference compared with the healthy individuals （P〉0.05）. Combined detection could not only increased the positive diagnosis rate of colorectal carcinoma, but also appraised the postoperative chemotherapy effect. Conclusion： Combined detection of CEA and CA199 can be used in diagnosing and evaluating the prognosis of colorectal carcinoma.
出处
《中国医药导报》
CAS
2009年第21期14-15,共2页
China Medical Herald
