2[1]Kino T, Hatanaka H, Hashimoto M, et al. FK-506, a novel immunosuppressant isolated from a Streptomycies.1. Fermentation, isolation, and physico-chemical and biological characteristics. [J]. J Antibiot, 1987,40:1249
3[2]Ireland RE, Liu LB, Roper TU, et al. Total synthesis of FK506. [J]. Tetrahedron, 1997, 53 (39): 13257
4[3]Caroline M, Spencer, Karen L, et al. Tacrolimus:an update of its pharmacology and clinical efficacy in the management of organ transplantation. [J]. Drugs, 1997, 54(6): 925
5[4]Dasgupta A,Timmerman TG. Therapeutic monitoring of tacrolimus using liquid chromatography. [J]. J Liq Chromatogr, 1995,18(20) :4029
6[5]Venkataramanan R, Swaminathan A, Prasad T,et al. Clinal pharmacokinetics of tacrolimus. [J]. Clin Pharmacokinet.1995,29(6) :404
7[6]Lampen A, Christians U, Guengerich FP, et al.Metabolism of the immunosuppressant FK in the small intestine: cytochrome P450, drug interactions and interindividual variability. [J]. Drug Metab Dispos, 1995,23 (12):1315
8[7]Winkler M ,Christians U,Stoll K, et al. Comparison of different assays for the quantitation of FK506 levels in blood or plasma. [J]. Ther Drug Monit ,1994,16(3):281
9[8]Warty V, Zuckermans, Venkataramanan R, et al.Tacrolimus analysis:A comparison of different methods and matrices. [J]. Ther Drug Monit, 1995,17 (2) : 159
10[9]Winkerler M, Christians U, Gonschior AK. Evauation of the new Pro-Trac tacrolimus, monoclonal whole blood ELISA for monitoring tacrolimus levels in patients after kidney , heart and liver transplant. [J]. Ther Drug Monit, 1995,17: 430
