摘要
白细胞介素18（IL-18）作为促炎因子，能够刺激NK细胞和T细胞，增强Th1／Th2免疫应答，在炎症反应和免疫反应中发挥着重要的作用。IL-18作为免疫佐剂应用于肿瘤治疗，具有抗肿瘤效应。IL-18高表达的肿瘤患者预后较差。IL—18也可促进肿瘤发展和免疫逃逸，诱导血管发生和转移。IL-18在肿瘤中的作用机制还需要进一步研究。
IL-18 was discovered as a proinflammatory cytokine, stimulates natural killer and T cells and enhances Th1/Th2 immune response, and plays a central role in inflammation and immune response.. Immune-stimulating effects of IL-18 as a adjuvent agent against cancer,have antineoplastic properities. However, Higher expression or secretion level of IL-18 is detected in the blood of the majority of cancer patients with poor prongnosis. IL-18 has also been associated with cancer progression and immune escape, is able to induce angiogenesis, metastasis. The dual effects of IL-18 in cancer need to be investigated further.
出处
《国际肿瘤学杂志》
CAS
2009年第7期501-504,共4页
Journal of International Oncology
