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2005-2008年广州市其他感染性腹泻流行特征分析 被引量:29

Analysis on epidemiologic characteristic of infectious diarrhea in Guangzhou,2005-2008
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摘要 目的了解广州市其他感染性腹泻流行病学特征,为有效控制感染性腹泻提供依据。方法对广州市2005-2008年疾病监测信息报告系统中上报的其他感染性腹泻病例进行描述性流行病学分析。结果2005-2008年广州市共报告其他感染性腹泻病例55081例,年发病率介于108.83/10万~152.78/10万之间,呈逐年上升趋势。5岁以下年龄组占全部发病数的64.49%。10-12月为发病高峰。报告发病率居前5位的地区为南沙、黄埔、花都、越秀和番禺。实验室诊断病例中,8789例有明确病原体信息,占报告病例总数的16.0%,其中轮状病毒、腺病毒及两者合并感染分别占实验室诊断病例的75.49%、10.83%和13.49%。共报告其他感染性腹泻暴发疫情7起,6起由诺如病毒引起。结论广州市2005-2008年其他感染性腹泻流行主要集中于0~5岁散居儿童,秋冬季是其他感染性腹泻的好发季节,轮状病毒为主要病原体,且存在轮状病毒和腺病毒交叉感染。降低轮状病毒性腹泻发病率是有效控制感染性腹泻的重要措施之一。 Objective To analyze epidemiologic characteristics of infectious diarrhea and to pro- vide basis for control measures in Guangzhou. Methods Descriptive epidemiologic method was applied to analyze characteristics of reported infectious diarrhea cases derived from routine infectious disease surveillance system during 2005 - 2008. Results Totally 55 081 infectious diarrhea cases were reported during 2005 -2008. The annual incidence was from 108. 83/100 000 - 152. 78/100 000 with ascending trend. The cases below 5 years age accounted for 64. 49% of the total. The incidence peak was in October and December. The top 5 districts of incidence in Guangzhou were Nansha, Huangpu, Huadu, Yuexiu and Panyu. The number of laboratory confirmed cases accounted for 16.0% of all cases. Rotavirus, enteric adenovirus and combined infections accounted for 75.49% , 10. 83% and 13.49% of laboratory confirmed cases, respectively. Seven outbreaks of infectious diarrhea were reported, six of which were caused by norovirus. Conclusion The infectious diarrhea was clustered in 0 -5 years old children, and peaked in au- tumn and winter seasons. Rotavirus was the major pathogen. There was combined infection of rotavirus and enteric adenovirus. One of the effective measures of control of infectious diarrhea was to reduce the rotavirus infection.
出处 《华南预防医学》 2009年第4期18-21,共4页 South China Journal of Preventive Medicine
基金 广州市医药卫生科技项目(2008yb118)
关键词 感染性腹泻 流行病学 轮状病毒 Infectious diarrhea Epidemiology Rotavirus
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  • 1方肇寅,张丽杰,唐景裕,章青,胡海宽,谢华萍,郑丽舒,Duncan Steele,Paul Kilgore,Joseph Bresee,Erik Hummelman,Xi Jiang,Roger Glass.中国河北省卢龙县儿童轮状病毒腹泻研究[J].病毒学报,2005,21(1):21-26. 被引量:41
  • 2方肇寅,晋圣瑾,秦树民,赵宪法,吴狄.PCR方法用于我国A组轮状病毒的分型研究[J].病毒学报,1994,10(4):316-321. 被引量:45
  • 3刘翼,戴迎春,姚英民,李建栋,詹惠春,陈清,俞守义,聂军.广州市某医院儿童秋冬季腹泻诺瓦克样病毒感染的分子流行病学研究[J].中华流行病学杂志,2005,26(7):525-528. 被引量:37
  • 4董巧丽,金玉,章菁,谢华萍,方肇寅.兰州地区婴幼儿轮状病毒和杯状病毒腹泻的研究[J].临床儿科杂志,2005,23(6):364-367. 被引量:15
  • 5Barnes GL, Bishop RF. Rotavirus infection and prevention[J]. Curr Opin Pediatic, 1997,9(1) : 19-23.
  • 6Ball JM, Tian P, Zeng CQ, et al. Age-dependent diarrhea induce by a rotavirus nonstructural glycoprotein [ J ]. Science, 1996,272 ( 5258 ) :101-104.
  • 7Pager CT, Alexander JJ, Steele AD, et al. South African G4P[6]asymptomatic and symptomatic neonatal rotavirus strains differ in their NSP4, VP8^*,and VP7 genes[J]. J Med Virol, 2000,62(2): 208-216.
  • 8Tian P, Estes MK, Hu Y, et al. The rotavirus nonstructural glycoprotein NSP4 mobilizes Ca2^+ from the endoplasmic reticulum [ J ]. J Virol,1995,69(9) : 5763-5772.
  • 9Zhang M, Zeng CQ, Dong Y, et al. Mutations in rotavirus nonstructural glycoprotein NSP4 are associated with altered virus virulence [ J ]. J Virol, 1998,72(5) : 3666-3672.
  • 10Estes MK, Kang G, Zeng CQ, et al. Pathogenesis of rotavirus gastroenteritis[ J]. Novartis Found Symp, 2001.238 : 82-96.

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