摘要
目的:探讨原发性青光眼患者血粘度水平改变及眼血流动力学变化对视神经的损害的意义及二者间的关系。方法:测定原发性开角型青光眼、急性闭角型青光眼、慢性闭角型青光眼和正常对照组(老年性白内障患者)各20例的全血比粘度、血浆比粘度、纤维蛋白原进行分析比较,并使用彩色多普勒成像技术检测其眼动脉(OA)和视网膜中央动脉(CRA)的收缩期血流速度(PSV)、舒张末期血流速度(EDV)、阻力指数(RI)、频谱形态和监听频声。各组间的均数差异比较用t检验,并将原发性青光眼患者的血流变指标分别与CDI血流动力学各项指标进行线性相关分析。结果:3组青光眼与对照组比较除纤维蛋白原差异无统计学意义外,其余各项血流变指标均显著升高;OA、CRA的PSV和EDV有明显下降,而RI明显增高;3组青光眼的血粘度各项指标与OA和CRA的PSV、EDV呈负相关,与RI呈正相关;正常对照组内血粘度水平与血流动力学各项指标无相关性。结论:原发性青光眼患者眼部存在不同程度的血液循环障碍,其血粘度水平升高可能是原发性青光眼视神经损害的潜在性危险因素;CDI对球后血管血流改变有较高的敏感性,在青光眼早期诊断及预后判断等方面均有重要的参考价值。
AIM： To investigate the relationship between levels of blood viscosity and ocular hemodynamic changes in patients of primary glaucoma （PG）. METHODS： The blood rheology indices （including whole blood, plasma, packed cell, relative blood viscosities and yield stress） were determined in primary open angle glaucoma （POAG） patients, primary acute angle closure glaucoma （PAACG） patients, primary chronic angle closure glaucoma （PCACG） patients and normal control group （patients with senile cataract）, 20 cases each group. The peak systolic velocity （PSV）, end diastolic velocity （EDV）, resistant index （RI）, shape of spectra and frequency of monitor of ophthalmic artery （OA） and central artery of retina （CRA） were detected with color Doppler imaging （CDI） simultaneously. Comparing to the differences of each group with ttest and giving a linear relational analysis to targets between the blood viscosity and hemodynamic of primary glaucoma patients. RESULTS： The blood rheology targets in PG groups were significantly higher than those in control group except fibrinogen. Comparing to control group, PSV and EDV in PG groups were significantly decreased but RI was remarkably increased. All targets of blood viscosity in PG patients were significantly negatively correlated with the PSV, EDV of both OA and CRA, but were significantly positively correlated with RI of OA and CRA. There were no significant correlations between the blood viscosity and ocular hemodynamics in the normal control. CONCLUSION： There are ocular blood circulation obstacles in and high level of blood viscosity PG patients, CDI has an important reference value in early diagnosis and prognosis of glaucoma.
出处
《国际眼科杂志》
CAS
2009年第8期1435-1438,共4页
International Eye Science
