摘要
乳腺癌的病因尚未明确,已知的危险因素包括生殖因素、影响体内性激素水平因素和遗传易感因素,但这些因素也只能解释约50%乳腺癌病例。近年来有研究试图从病毒感染的角度探讨乳腺癌的病因,EB病毒(Epstein-Barr virus,EBV)正是研究热点之一。但EBV与乳腺癌的关系仍存在着很大的争议。本文就EBV生物学特点、EBV与乳腺癌的相关性研究(包括癌组织中的EBV检测、血清学研究、细胞学实验和临床特点分析)作一综述,并提出目前存在的问题和今后研究的方向。
The etiology of breast cancer factors, including reproductive and other s still unclear. The factors affecting well-known risk circulating sex hormones, and genetic susceptibility, explain only about 50% of all breast cancer incidence. More and more studies have shown interest in the possibility that breast cancer may be caused by viral infection. Epstein-Barr virus （EBV） is one of the candidate viruses, but the association of EBV with breast cancer remains controversial. Here we reviewed the studies on EBV biology and the association of EBV with breast cancer, including EBV detection in breast cancer tissues, serological tests, cytologic experiments and clinical analyses, and described the limitations of current studies and future directions
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2009年第8期827-830,共4页
Chinese Journal of Cancer
关键词
EB病毒
乳腺肿瘤
相关性
Epstein-Barr virus, breast neoplasm, association
