摘要
目的调查北京地区肺炎链球菌对青霉素等抗生素的耐药率。方法用Ｅｔｅｓｔ及琼脂稀释法测定临床分离的７９株肺炎链球菌１５种抗生素的最低抑制浓度（ＭＩＣ）。结果Ｅｔｅｓｔ测得１０株（１２．７％）低耐青霉素（ＭＩＣ０．１２５～１μｇ／ｍｌ），１株（１．３％）高耐青霉素（ＭＩＣ４μｇ／ｍｌ）；仅１株处于头孢曲松、头孢噻肟中介范围（ＭＩＣ１μｇ／ｍｌ）．琼脂稀释法测得阿莫西林、阿莫西林／棒酸、头孢呋肟、环丙沙星、氯霉素、四环素、红霉素的耐药率分别为１．３％、１．３％、２．５％、２．５％、１６．５％、４９．４％、４０．５％，所有菌株对头孢曲松、万古霉素敏感。结论北京地区１４％的肺炎链球菌耐青霉素，耐三代头孢菌素及多重耐药株罕见。
Objective To investigate antibiotic resistance patterns of Streptococcus pneumoniae in Beijing. Methods The minimal inhibitory concentration (MIC) of 79 strains were detected by E test and agar dilution. Results Ten (12.7%) of the 79 strains were penicillin intermediate resistance (MIC 0.125-1μg/ml) and 1(1.3%) strain was penicillin resistance (MIC 4μg/ml) by E test;Only 1 strain (1.3%) was intermediate resistance (MIC 1μg/ml) to ceftriaxone and cefotaxime.By agar dilution method,the percentage of resistance to amoxicillin,amoxicillin/clavulanic acid,cefuroxime,ciprofloxacin, chloramphenicol,tetracycline and erythromycin was 1.3%,1.3%,2.5%,2.5%,16.5%,49.4% and 40.5%,respectively;No resistant strains to ceftriaxone and vancomycin were detected. Conclusions The resistant rate of S.pneumoniae to penicillin was 14% in Beijing.Few strains were resistant to third generation cephalosporins and multiple drugs.
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
1998年第4期309-313,共5页
Chinese Journal of Microbiology and Immunology
关键词
肺炎球菌
抗生素
耐药性
Streptococcus pneumoniae Antimicrobial resistance
