摘要
[目的]了解广西壮族自治区隆安县HBsAg携带者血清乙型肝炎病毒（HBV）DNA、丙氨酸氨基转移酶（ALT）情况。[方法]对广西隆安县30～55岁HBsAg携带者组成的研究队列采空腹静脉血，利用套式聚合酶链激反应（nPCR）检测血清HBV DNA，利用赖氏法测血清ALT，根据HBV DNA检测结果将研究对象分为两组，HBVDNA（＋）组和HBVDNA（-）组。比较人群ALT异常率。[结果]HBsAg携带者HBV DNA阳性率为53．34％（1008／1855），ALT异常率为17．41％（323／1855），男性HBVDNA阳性率（56．69％，589／1039）、ALT异常率（22．14％，230／1039）均高于女性（51．35％、419／816，11．40％、93／816）（均P〈O．05），HBVDNA（＋）组ALT异常率（23．21％）高于HBVDNA（-）组（10．51％）（Pd0．01）；40～岁年龄组ALT异常率（19．18％）最高，各年龄组ALT异常率的差异无统计学（P〉0．05）。[结论]该地区HBsAg携带者高HBV复制率、肝功能受损是肝癌高发的危险因素之一。
[Objective]To understand the examination result of HBV DNA and alanine aminotransferase （ALT） among HBsAg carriers in Longan county of Guangxi. [Methods]Fasting venous blood samples from HBsAg carriers study cohort aged 30-55 years old living in Longan county of Guangxi were colected. Sera were tested for hepatitis B viral DNA using nested polymerase chain reaction （nPCR）. ALT was examined with King＇s method. The study subjects were divided into two groups. The first group was positive for HBV DNA. The second group was negative for HBV DNA. ALT abnormal rate of every group was compared. [Results]The positive rate of HBV DNA in HBsAg carriers is 53.34 % （1 008/1 855）. The total ALT abnormal rate is 17.41%（323/1 855） ,and male＇s HBV DNA positive rate（56.69%,589/1 039） and ALT abnormakate（22.14% ,230/1 039） washigherthanthatoffemale＇s（51.35% ,419/816;11.40% ,93/816）（bothP〈0.05）. ALT abnormal rate（23.21%）in the group with positive HBV DNA was significantly higher than that of the group with negative HBV DNA＇s（10.51%）（P〈0.01）.The highest ALT abnormal rate（19.18%） was the group aged from 40- age. The ALT abnormal rate in each age group was no significant difference（ P 〉0.05）. [Conclusion]One of the important factors that caused high incidence of PLC was high HBV replication rate and liver function damage in HBsAg carriers in Longan county.
出处
《预防医学论坛》
2009年第8期673-674,709,共3页
Preventive Medicine Tribune
基金
英国Wellcome基金会资助项目(072058/Z/03/Z)
