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肿瘤骨桥蛋白相关信号通路研究进展 被引量：3

Role of osteopontin in tumor signaling pathway
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摘要 骨桥蛋白（OPN）为一种分泌型、趋化因子样、糖基化的细胞外基质结合蛋白，与其主要受体整合素和CD44结合，参与调节体内多器官多组织的病理生理过程。OPN相关的信号转导在肿瘤发生、演进过程中扮演重要的角色，OPN有望成为肿瘤生物学治疗的新靶点。 Osteopontin （OPN）is a secretory, chemokine-like, glycosylated ECM-assoeiated protein that interacts with integrins and CD44. OPN plays a crucial role in both physiological and pathological processes in varieties of organs and tissues. Since its flint identification in bone, the multifaceted roles of OPN have been an area of intense investigation. Extensive research suggests the important role of OPN in regulating the cell signaling contributes to tumor progression and metastasis. This review focuses on recent advances on functional roles of the OPN-induced signaling pathway in the regulation of cell migration and tumor progression and implications for identifying novel targets for cancer therapy.
作者 孙冰生(综述) 王长利(审校)
机构地区 天津医科大学附属肿瘤医院肺部肿瘤外科 天津市肺癌诊治中心天津市肿瘤防治重点实验室
出处 《国际肿瘤学杂志》 CAS 2009年第8期569-571,共3页 Journal of International Oncology
关键词 骨桥蛋白 肿瘤 信号转导 Osteopontin Neoplasms Signal transduction
分类号 R543.5 [医药卫生—心血管疾病] R730.231 [医药卫生—肿瘤]
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参考文献24

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同被引文献31

  • 1杨晓清,滕良珠.脑膜瘤增殖与复发的分子生物学机制研究进展[J].山东医药,2006,46(30):76-77. 被引量：2
  • 2俞文华,张国新.骨桥蛋白:一种新的肿瘤标志物[J].国际检验医学杂志,2006,27(12):1109-1111. 被引量：8
  • 3庄亚强,莫军扬,朱其一,梁志东,杨建青.应用RT-PCR检测CK19在乳腺癌前哨淋巴结表达的临床研究[J].华夏医学,2007,20(1):43-44. 被引量：1
  • 4Senger DR, Wirth DF, Hynes RO. Transformed mammalian cells secrete specific proteins and phosphoproteins[J]. Cell, 1979,16 (4):885 893.
  • 5Stathopoulou A,Mavroudis D,Perraki M, et al. Molecular detec tion of cancer cells in the peripheral blood of patients with breast cancer: comparison of CK-19,CEA and maspin as detection mark ers[J]. Anticancer Res, 2003,23 (2C) : 1883-1890.
  • 6Zaretsky JZ, Barnea I, Aylon Y, et al. MUC1 gene overexpressedin breast cancer:structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ER alpha) in regu lationof the MUC1 gene expression[J]. Mol Cancer, 2006,5 : 57-70.
  • 7Mohamed F,Vincent N,Cottier M,et al.Improvement of malignant serous effusions diagnosis by quantitative analysis of molecular claudin 4 expression[J].Biomarkers,2010,15(4):315-320.
  • 8Zhao S,Yang H,Zhang M,et al.Circulating tumor cells(CTCs)detected by triple-marker Ep CAM,CK19,and h MAM RT-PCR and their relation to clinical outcome in metastatic breast cancer patients[J].Cell Biochem Biophys,2013,65(2):163-173.
  • 9Kong Y,Wang J,Liu W,et al.Cytokeratin19-2g2,a novel fragment of cytokeratin19 in serum,indicating a more invasive behavior and worse prognosis in breast cancer patients[J].PLo S One,2013,8(2):e57092.
  • 10周龙,雷建平,李瑶.粘蛋白(MUC1)与肿瘤的关系[J].江西医药,2008,43(4):364-367. 被引量：5

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国际肿瘤学杂志
2009年 第8期

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