摘要
目的:对甲氧沙林脂质体(LMOP)凝胶的毒理进行考察,以评价其生物安全性。方法:以豚鼠为实验动物,观察豚鼠完整皮肤及破损皮肤短时间接触LMOP凝胶后所产生的毒性反应情况以及单次与多次接触LMOP凝胶后所产生的局部刺激反应,并通过动物皮肤重复接触LMOP凝胶后,观察机体免疫系统在动物皮肤上的反应。结果:LMOP在豚鼠完整或破损皮肤局部均无明显刺激性及毒性,多次使用LMOP后,全身也无明显的毒性反应。结论:LMOP具有较高的皮肤应用安全性,值得进一步研究。
Objective： To Study the pharmaco-toxical action of Methoxsalen lipogels （LMOP） in order to evaluate its biotic safety. Method： Guinea-pigs were used as test animal, the toxic action and local irritation in complete and damaged skin were observed after treated by LMOP. The general toxicity was also investigated after repeat treated by LMOP. Result： None the tests showed the significant toxic action, local irritation or general toxicity. Conclusion： LMOP with promising skin application safety was valuable to be studied further.
出处
《中国药师》
CAS
2009年第9期1255-1256,共2页
China Pharmacist
关键词
甲氧沙林
脂质体凝胶
毒理
Methoxsalen
Lipogels
Pharmaco-toxical action
