摘要
目的探讨细胞色素Ｐ４５０１Ａ１（ＣＹＰ１Ａ１），２Ｄ６（ＣＹＰ２Ｄ６）和谷胱甘肽硫转移酶（ＧＳＴＭ１）基因多态性与肺癌易感性的关系。方法用病例对照研究方法及ＰＣＲ┐ＲＦＬＰ等技术检测原发性肺癌和住院对照各５９例，分析ＣＹＰ１Ａ１基因ＭｓｐＩＣ型、ＣＹＰ２Ｄ６Ｃｈ型（Ｔ／Ｔ型）和ＧＳＴＭ１缺陷型〔ＧＳＴＭ１（－）〕三种纯合突变型频率分布及其交互作用。结果突变型在病例和对照组的频率分别为（ＣＹＰ１Ａ１ＭｓｐＩＣ型２５．４％、１５．３％（Ｐ＝０．１７），ＣＹＰ２Ｄ６ＣｈＴ／Ｔ型３５．６％，４７．５％（Ｐ＝０．２６），ＧＳＴＭ１（－）型５７．６％、４９．２％（Ｐ＝０．４６），无显著性差异。协同分析发现在男性中，１１．６％（５／４３）肺癌兼有ＭｓｐＩＣ型和ＧＳＴＭ１（－）型，对照组无１例（０／４３），Ｐ＝０．０３。结论结果提示在男性中ＣＹＰ１Ａ１ＭｓｐＩＣ型和ＧＳＴＭ１（－）型可能协同增加患肺癌的危险性。
Objective The genetic polymorphisms of CYP 1A1,CYP 2D6 and glutathione Stransferase M1 (GST M1) were analysed probed for the genetic markers of lung cancer. Methods The casecontrol study was conducted among 59 lung cancer cases and 59 hospitalized controls.The genetic polymorphisms were tested with method of PCRRFLP. Results The frequences of CYP 1A1 MspI C,CYP 2D6Ch T/T and GST M1(-) homozygous alleles were 254%,356% and 576% respectively in lung cancer group,while 153%,475% and 492% in control group,P>005.Combined analysis of the polymorphisms showed that significant higher frequences of both MspI C and GST M1(-) genotypes existed in the male lung cancer (5/43,116%) than in the control (0/43 P=003). Conclusion There may be a synergistic interaction between MspI C and deficient GST M1 on the elevated susceptibility of lung cancer in male.
出处
《肿瘤》
CAS
CSCD
北大核心
1998年第4期269-271,共3页
Tumor
基金
美国纽约中华医学基金
1994年卫生部基金
