摘要
采用微量平板稀释法测定肝胆外科病人口服左氟沙星后的血清和胆汁的杀菌效价。结果表明，左氟沙星对链球菌、变形杆菌、肺炎克雷伯氏菌杀菌活性最强，血清杀菌效价为１８～１１６，胆汁杀菌效价为１３２～＞１２５６，且杀菌作用能维持在８ｈ以上；对大肠埃希氏菌、金葡球菌杀菌作用较强，胆汁杀菌效价为１８～１１６，其杀菌作用也能维持８ｈ以上，但其血清杀菌效价为１４，对铜绿假单胞单胞菌的杀菌作用较低。
The serum and bile bactericidal activities after oral adminstration of levofloxacin (LVLX) were determined by broth microdilution method. The result showed that the bactericidal activities of LVLX against Streptococcus, Proteus and K. pneumoniae were the highest, the serum bactericidal activity (SBA) of LVLX were 1∶8-1∶16, the bile bactericidal activity (BBA) were 1∶32->1∶256, the bactericidal activity lasted more than 8h. The activity was high against E.coli and S.aureus, the BBA of LVLX were 1∶8-1∶16, the SBA were 1∶4, the activity lasted more that 8h too. LVLX showed low activity against P.aeruginosa, there was no activity after 8h.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1998年第4期312-314,共3页
Chinese Journal of Antibiotics
关键词
左氟沙星
血清
杀菌效价
胆汁
Levofloxacin
Serum bactericidal activity
Bile bactericidal activity
