摘要
苦瓜(Momordica charantia L.)为葫芦科苦瓜属植物,是一种在全世界广为种植的常用蔬菜。中医认为苦瓜具有清热解毒、滋养强壮、降低血糖等功效,在民间用于治疗II型糖尿病。本文报道了从苦瓜中分离得到的8个化合物,用波谱学方法分别鉴定为苦瓜内酯(1)、苦瓜酚苷A(2)、二氢菜豆酸3-O-β-D-吡喃葡萄糖苷(3)、6,9-二羟基-megastigman-4,7-二烯-3酮(4)、鸟苷(5)、腺苷(6)、尿嘧啶(7)和胞嘧啶(8)。其中化合物1和2为新化合物,3～5为首次从该植物中分离得到。
Momordica charantia L. is a vegetable widely cultivated around the world. Its fruits have been used in Asian countries as a folk medicine for the treatment of non-insulin-dependent diabetes mellitus. Here we report eight compounds isolated from the fruits of M. charantia. On the basis of NMR and MS spectroscopic analyses, these compounds were identified as momordicotide （（10E）-3-hydroxyl-dodeca-10-en-9-olide, 1）, monordicophenoide A （4-hydroxyl-benzoic acid 4-O-β-D-apiofuranosyl （1→2）-O-fl-D-glucopyranoside, 2）, dihydrophaseic acid 3-O-β-D-glucopyranoside （3）, 6,9-dihydroxy-megastigman-4,7-dien-3-one （blumenol, 4）, guanosine （5）, adenosine （6）, uracil （7） and cytosine （8）. Among them, 1 and 2 are new compounds. Compounds 3-5 were isolated from this plant for the first time.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第9期1014-1018,共5页
Acta Pharmaceutica Sinica
关键词
苦瓜
苦瓜内酯
苦瓜酚苷A
Momordica charantia
momordicolide
monordicophenoide A
