摘要
目的:探讨抵当汤对高血压脑出血(急性期)各型患者细胞因子的影响。方法:将196例高血压脑出血患者随机分为治疗组和对照组,根据中医分型分为风痰瘀血型、肝阳暴亢型、痰热腑实型和气虚血瘀型,治疗组各型在综合治疗的基础上加抵当汤治疗。分别于不同时点抽血5mL,用双夹心酶联免疫吸附法(ELISA)检测肿瘤坏死因子(TNF-α)、白细胞介素(IL)-6、IL-8和IL-10。结果:治疗组风痰瘀阻型、肝阳暴亢型、痰热腑实型患者血清中TNF-α、IL-6、IL-8、IL-10水平与治疗前相比均有统计学意义(P<0.01);与对照组比较也有统计学意义(P<0.01)。治疗组气虚血瘀型治疗后与治疗前比较差异无统计学意义(P>0.05)。结论:抵当汤可降低高血压脑出血风痰瘀阻型、肝阳暴亢型、痰热腑实型患者促炎性因子,提高抗炎性因子(IL-10)水平,从而减少炎症反应。
Objective：To evaluate the effect of Didang tang on eytokines in patients with hypertensive Cerebral hemorrhage. Methods ：196 patients with hypertensive cerebral hemorrhag were differentiated into four syndrome type based on the TCM, Typel （ Feng Tan Yu Xue）, Type2 （ GanYang BaoKang）, Type3 （ TanRe FuShi ）, Typed （ QiXu XueYu）, were randomized into the Didangtang group and the control group, were treat by general treatment as well as Didang tang given per os. Blood Sample were collect- ed at different time point during and after Didangtang for cytokines determination,including tumor necrosis factor α（ TNF-α）, interleukin- 6（ IL- 6）, IL- 8 and IL- 10 by ELISA. Results：All the indexes measured were insignificantly different between groups before treatmet. Compered with theFengTan YuXue and the GanYang BaoKang and the TanRe FuShi the serum that level of TNF -α,IL - 6 and IL - 8 decreased significantly（P 〈0.01 ）. while those of IL - I0 were highert in the Didangtang treatment（P 〈 O. O1 ）. but the QiXu XueYu the serum that level of TNF -α, IL - 6, IL - 8 and IL - 10 was no significantly（ P 〉 O. 05 ）. Conchsion： Didangtang may decrease the inflammation cytokine promoting factors, and increase the level of anti - inflammatory cyto- kine（IL- 10） ,So it Could attenuato the inflammation reation in patients after hypertensive cerebral hemorrhage.
出处
《辽宁中医杂志》
CAS
北大核心
2009年第9期1506-1508,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
抵当汤
高血压
脑出血
细胞因子
中医证型
Didangtang
hypertensive
cerebral hemorrhage
cytokine
TCM syndrome type
