人参皂苷Re对肾脏缺血再灌注损伤大鼠肾功能及ATP酶的影响被引量：16

The effects of kidney function and ATP enzymes of Ginsenoside Re on rat kidney of ischemia-reperfusion injury

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摘要目的探讨人参皂苷Re对肾脏缺血再灌注损伤大鼠肾脏的影响。方法30只Wistar大鼠分为假手术组、模型组和治疗组,每组10只。观察人参皂苷Re对大鼠缺血再灌注损伤肾功能和肾脏组织Na+-K+-ATP酶、Ca2+-ATP酶的影响。结果模型组大鼠Scr、BUN急剧上升,与假手术组比较有显著性差异(P<0.01),治疗组Scr、BUN显著下降,与模型组比较有明显差异(P<0.01,0.05);模型组肾脏组织Na+-K+-ATP酶和Ca2+-ATP酶的活性显著低于假手术组(P<0.01),人参皂苷Re可提高Na+-K+-ATP酶和Ca2+-ATP酶的活力(P<0.05)。结论人参皂苷Re可以改善肾脏缺血再灌注损伤大鼠肾功能,其机制与保护肾脏钠泵和钙泵功能有关。 Objective To study the protective effects of Ginsenoside Re on rat kidney of ischemia-reperfusion injury.Methods The model of Wistar rat kidney of ischemia-reperfusion injury was established and 30 Wistar rats were divided into 3 groups. We studied the effects of kidney function and ATP enzymes of Ginsenoside Re on rat kidney of Ischemia-reperfusion injury. Results The levels of seru;n creatinine and blood urea nitrogen of Wistar rats in model group were higher than that in sham-operated group（ P 〈 0.01 ）, while the levels of serum creatine and blood urea nitrogen in treatment group decreased（ P 〈 0.01,0.05）. The energy of Na＋ - K ＋ -ATP enzyme and Ca2 ＋ -ATP enzyme in rat kidneys in model group was lower than that in sham-operated group（ P 〈 0.01 ）, Gin- senoside Re can improve the energy of Na ＋ -K ＋ -ATP enzyme and Ca2 ＋ - ATP enzyme in rat kidneys（ P 〈 0.05）. Conclusion Ginsenoside Re can improve the rat kidney function of ischemia-repeffusion injury by its protection on natrium pump and calcium pump in rat kidneys.

作者曹霞谷欣权陈燕萍马兴元

机构地区吉林大学药学院吉林大学中日联谊医院吉林大学化学院

出处《中国实验诊断学》北大核心 2009年第8期1025-1027,共3页 Chinese Journal of Laboratory Diagnosis

基金国家自然科学基金资助(30701128)

关键词人参皂苷RE 缺血再灌注损伤肾脏 Ginsenoside Re Ischemia-reperfusion Injury Kidney

分类号 R285.5 [医药卫生—中药学]

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