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中晚孕期孕妇血清抑制素A水平及其与胎儿非整倍体的相关性初探 被引量：5

Study on the correlation between serum inhibin A level of women at the second and third trimester and fetal aneuploid
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摘要 目的:建立正常孕妇血清抑制素A在孕中晚期各孕周的参考值,探讨孕妇血清抑制素A水平异常与胎儿染色体非整倍体可能存在的相关关系。方法:采用酶链免疫吸附技术(ELISA)试剂盒测定孕妇血清抑制素A浓度,按完全孕周分别统计出各孕周正常孕妇的血清抑制素A中位数值;比较唐氏综合征和18-三体综合征妊娠的血清抑制素A水平异常。结果:昆明地区孕14～36周共计2592例正常单胎妊娠孕妇的血清抑制素A浓度中位数分别是:351.0、315.5、259.0、265.0、281.0、265.5、302.0、326.0、371.0、423.5、417.0、450.0、532.0、685.5、703.0、628.0、838.0、926.0、743.0、882.0、1340.0、1260.0、1490.0pg/ml。经产前诊断证实的9例胎儿染色体数目异常中有6例孕妇血清抑制素A水平异常。结论:孕妇血清抑制素A水平异常与胎儿染色体非整倍体存在一定的相关性,在血清标记物中加入血清抑制素A有可能提高产前筛查的检出率;建立各孕周孕妇血清抑制素A的正常值,可以为本地区产前筛查以及其他妊娠相关疾病的研究提供参考。 Objective： To establish the serum inhibin -A referential values of normal pregnant women at each second and third - trimester week, explore the correlation between serum inhibin A level of pregnant women and fetal aneuploid. Methods： Serum inhibin A levels of the women were detected by ELISA, and the median values for each gestational week were summarized, respectively. The maternal serum inhibin A levels of Down syndrome and trisomy 18 syndrome were compared. Results： 2 592 serum samples from normal, singleton pregnant women at 14 -36 gestational weeks were tested. The median values for each completed gestational weeks were 351.0, 315.5, 259.0, 265.0, 281.0, 265.5, 302.0, 326.0, 371.0, 423.5, 417.0, 450.0, 532.0, 685.5, 703.0, 628.0, 838.0, 926.0, 743.0, 882. 0, 1 340. 0, 1 260. 0 and 1 490. 0 pg/ml, respectively. Abnormal maternal serum inhibin A levels were found in 6 cases among 9 cases with Down syndrome or trisomy 18 syndrome pregnancies verified by prenatal diagnosis. Conclusion： Abnormal maternal serum inhibin A levels have some associations with the fetal chromosomal aneuploid. It is possible to increase the detection rate when inhibin A is added into the serum markers in the prenatal screening. Setting up the normal values of maternal serum inhibin A at various gestational weeks is valuable for the researches on prenatal screening and gestation - related diseases in local populations.
作者 史纪芳 朱宝生 董旭东 叶汉风 焦存仙 朱姝 苏洁 李苏云
机构地区 昆明医学院附属昆华医院.云南省第一人民医院遗传诊断中心 云南省第一人民医院产科 云南省人口与计划生育科研所
出处 《中国妇幼保健》 CAS 北大核心 2009年第27期3782-3784,共3页 Maternal and Child Health Care of China
基金 云南省自然科学基金重点项目(编号:2003C0018Z) 云南省"十五"科技攻关项目(编号:2004NG15)资助
关键词 抑制素A 孕妇 血清 非整倍体 产前筛查 Inhibin A Pregnant women Sermn Aneuploid Prenatal screening
分类号 R714.5 [医药卫生—妇产科学]
  • 相关文献

参考文献8

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二级参考文献17

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共引文献71

同被引文献85

  • 1满婷婷,廖灿.Inhibin-A及其在中孕期唐氏综合征筛查中的应用[J].中国产前诊断杂志（电子版）,2011,3(2):21-28. 被引量：2
  • 2梁启峰.妊娠相关血浆蛋白-A与妊娠关系[J].广东医学,2006,27(12):1863-1865. 被引量：1
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  • 5HuttlyW,Rudnicka A,Wald NJ.Second-trimester prenatal screening markers for Down syndrome in women with insulin-dependent diabetes mellitus. Prenatal Diagnosis . 2004
  • 6Cuckle HS,Holding S,Jones R,et al.Combing inhibin A with existing second-trimester markers in maternal serum screening for Down’’s syndrome. Prenatal Diagnosis . 1996
  • 7de Kretser DM,Robertson DM.Theisolation and physiology of inhibin and related proteins. Biology of Reproduction . 1989
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  • 9McLachlan RI,Healy DL,Lutjen PJ,et al.The maternal ovary is not the source of circulating inhibin levels during human pregnancy. Clinical Endocrinology . 1987
  • 10Muttukrishna S,George L,Fowler PA,et al.Measurement of serum concentrations of inhibin-A (alpha-beta A dimer)during human pregnancy. The Journal of Clinical Endocrinology . 1995

引证文献5

二级引证文献13

中国妇幼保健
2009年 第27期

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