摘要
目的:氧化低密度脂蛋白(ox-LDL)在动脉粥样硬化(AS)的发生、发展过程中均发挥着重要作用,本研究旨在探讨ox-LDL水平与冠心病病变程度及其他危险因素的关系。方法:164例行冠状动脉造影(CAG)患者根据造影结果分为对照组29例和冠心病(CHD)组135例。收集空腹静脉血,用酶法检测ox-LDL水平。CHD组患者按不同的标准分急性心肌梗死(AM I)、不稳定心绞痛(UA)及稳定性心绞痛(SA)组;单支、双支及多支病变组;局限及弥漫病变组;轻度、中度及重度狭窄组。结果:ox-LDL水平在AM I组[(85.60±29.21)μg/m l]高于UA组[(72.54±27.75)μg/m l]及SA组[(72.93±26.50)μg/m l](P=0.05,P=0.06);多支病变组[(83.78±29.66)μg/m l]较单支病变组[(68.57±26.50)μg/m l]明显升高(P<0.01);重度狭窄组[(81.43±29.19)μg/m l]较轻度狭窄组[(64.95±25.96)μg/m l]和中度狭窄组[(70.87±24.82)μg/m l]均明显升高(P<0.05);CHD组虽较对照组高,但差异无统计学意义(P>0.05)。相关分析显示ox-LDL与TC及冠脉狭窄程度关系较大。结论:ox-LDL水平与CHD病变严重程度呈一定相关性。
Objective： Oxidized low density lipoprotein（ox-LDL） plays an important role in the pathogenesis and development of atherosclerosis.The aim of this study was to explore the relationship of the ox-LDL level with the severity and risk factors of coronary heart disease（CHD）.Methods： A total of 164 patients undergoing coronary angiography（CAG） were assigned to a control group（n=29） and a CHD group（n=135） according to the results of CAG.The samples of fasting plasma were collected,and the levels of ox-LDL were detected by ELISA. Based on different criteria of classification, the CHD patients were again divided into the following subgroups： acute myocardial infarction （AMI）, unstable angina （UA）, stable angina （SA）, single-vessel disease （SVD）, double-vessel disease （DVD）, multivessel disease （MVD） , localized lesion, diffuse lesion, slight stenosis group, moderate stenosis, and severe stenosis. Results ： The level of ox-LDL was higher in the AMI （85.60±29.21 μg/ml ） than in the UA （72.54 ± 27.75 μg/ml） and SA groups （72.93 ± 26.50 μg/ml）, with statistically significant differences （P = 0.05 and P = 0.06）. It was significantly higher in the MVD （83.78 ± 29.66 μg/ml） than in the SVD group （68.57 ± 26.50 μg/nd, P 〈 0.01）, and so was it in the severe （81.43 ±29.19 μg/ml） than in the slight （64.95 ± 25.96 μg/ml, P 〈 0.05） and moderate stenosis groups （70.87±24.82 μg/ml, P 〈 0.05）, respectively. It was also higher in the CHD than in the control group, but with no significant difference. Multiple regression analysis showed that the level of ox-LDL was strongly correlated with the severity of CHD. Conclusion ： There is a relationship between the level of ox-LDL and the severity of CHD.
出处
《医学研究生学报》
CAS
2009年第9期951-955,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金资助项目(批准号:30872411)
关键词
氧化低密度脂蛋白
冠心病
危险因素
Oxidized low density lipoprotein
Coronary heart disease
Risk factor
