摘要
耐药相关蛋白(LRP)又叫主穹隆蛋白(MVP),是一种在人体内普遍表达的蛋白,构成了细胞内已知的最大蛋白质之一——穹隆体,并参与核孔复合物的组成,对细胞核质物质转运起重要作用。随着对其的深入研究,发现LRP在细胞的生理代谢、自身保护、抗凋亡、抗感染、肿瘤的恶变以及多药耐药(MDR)的形成等过程中起着重要作用,同时其表达程度与肿瘤治疗效果以及预后也有一定的相关性。
Lung resistance-related protein （LRP）, also named as major vault protein （MVP） , is widely expressed in human tissue. It constructs one of the largest protein in cell which is called Vault. It is a main component of nuclear pore complex and plays an important role in nucleo-cytoplasmic transport. It is shown that LRP plays an important role in the metabolism, conservation, anti-apoptosis, anti-infection, as well as in the development of multidurg resistance and canceration of tumors. At the same time, researches show that the expression of LRP is correlated with the curative effect and prognosis of tumor.
出处
《医学综述》
2009年第19期2944-2948,共5页
Medical Recapitulate
基金
广西科学研究与技术开发计划(桂科攻0322024-1A)
关键词
肺耐药相关蛋白
穹隆
多药耐药
肿瘤
Lung resistance-related protein
Vault
Multidrug resistance
Tumor
