摘要
目的观察前列地尔(PGE1)联合培多普利(ACEI类药物)治疗早期糖尿病肾病(DN)的疗效。方法将96例早期DN患者,随机分为联合治疗组50例,培多普利组46例。两组控制血压、血糖方法相同,均服用培多普利4mg,每日1次。联合治疗组同时静脉注射PGE110μg,每日1次,连续14d。结果联合治疗组于治疗2周后24h尿蛋白及白蛋白排泄率较治疗前明显降低(P<0.01),同时和培多普利组相比,下降也明显(P<0.01);治疗3个月后尿蛋白仍维持在较低水平。培多普利组仅在治疗3月后尿蛋白较治疗前明显减少(P<0.01)。结论在DN早期阶段,联合使用PGE1和培多普利可快速降低尿白蛋白排泄率,并使尿蛋白长期维持在较低水平,提示培多普利联合PGE是治疗早期DN的有效方法。
[ Objective] To observe the therapeutic effects of combined treatment of aiprostadil （ PGE-1 ） with perindopril （ ACEI ） against early diabetic nephropathy （ DN ） in patients. [ Methods ] Totally 96 cases of early DN were randomly divided into combined treatment group （ 50 eases） and perindopril group （ 46 cases ）, perindopril 4rag was administrated to both 2 groups. Intravenous in- jection of PGE 110μg was administrated to combined treatment group per day for continuous 14 days. [ Results] After 2 weeks of treatment , 24-hour urine protein and albumin excretory rate were significantly decreased in combined treatment group, compared with that of pretreatment （ P 〈0.01 ）, and it also lower than that of perindopril group. After 3 months of treatment, urine protein main- tained at a low level, while that of perindopril group significantly decreased [ P 〈0.01 ）. [ Conclusion] In the early stages of DN, combined treatment with alprostadil and perindopril can quickly reduce the urinary albumin excretion rate, and makes the urine pro- tein maintain at a low level which indicates that perindopril combined PGE-I is an effective treatment of early DN.
出处
《职业与健康》
CAS
2009年第22期2453-2455,共3页
Occupation and Health
