摘要
DNA甲基化是一种在DNA序列不变情况下的DNA生物修饰方式。一般来说,基因表达水平与DNA甲基化呈负相关,异常CpG岛的甲基化可诱导基因沉默。去甲基化治疗就是用药物清除启动区的甲基,使因高甲基化而关闭的抑癌基因重新表达,达到治疗肿瘤的目的。去甲基化治疗作为一种新的治疗途径可能对防止恶性血液病化疗耐药及复发有一定作用。本文对DNA甲基化的机制、DNA甲基化异常与恶性血液病的关系、DNA去甲基化治疗的机理以及恶性血液病(急性、慢性白血病、淋巴瘤以及骨髓增生异常综合征)去甲基化治疗的研究进展进行了综述。
DNA methylation is an important and reversible epigenetic modification which regulates genomic stability. Methylation is essential for mammalian development. Generally, gene expression level and DNA methylation are negative correlation. Transcriptional silencing via methylation of CpG islands in the promoter is important for cell growth and differentiation and plays a key role in tumorigenesis. Demethylation drug can modify chromatin and restore the ability of anti-oncogene. Demethylation therapy as a new therapy may treat efficiently hematological malignancies with resistance and relapse. In this review, DNA methylation mechanism, relationship between aberrant methylation and hematologic malignancies, mechanism of demethylation therapy, the advance of research on the demethylation therapy of hematological malignancies, such as acute and chronic leukemia, lymphoma, myelodysplastic syndrome were summarized.
出处
《中国实验血液学杂志》
CAS
CSCD
2009年第5期1394-1398,共5页
Journal of Experimental Hematology
关键词
去甲基化治疗
恶性血液病
DNA甲基化
demethylation therapy
hematological malignancy
DNA methylation
