摘要
目的:观察注射用丹红对犬冠状动脉结扎造成心肌梗塞模型的治疗作用。方法:采用麻醉犬冠状动脉左前降支结扎造成心肌梗塞模型,测定犬心外膜电图,硝基四氮唑兰(N-BT)染色确定心肌梗塞面积和血清肌酸激酶(creatine kinase,CK)及乳酸脱氢酶(lactate dehydrogenase,LDH)测定。结果:注射用丹红2、6、12 g生药/kg静注可显著降低犬冠脉结扎后心肌缺血的程度,显著缩小心肌梗塞范围,显著降低冠脉结扎犬ST段升高总毫伏(mV)数(∑-ST)和ST段升高总点数(N-ST),显著降低血清LDH、CK升高的程度,作用强度与剂量有一定的关系。结论:注射用丹红能显著减轻犬心肌梗塞时的心肌缺血程度和范围,对犬心肌梗塞有治疗作用。
Objective：To investigate the therapeutical effects of Danhong for injection on myocardial infarction model induced by coronary artery ligation in dogs. Methods ： The models of myocardial infaretion were produced by ligation of the left anterior descending coronary artery in the anaesthetized dogs. The extent of myocardial ischemia and infarction was determined by means of epicardial mapping and N-BT staining. The parameters of lactate dehydrogenase and creatine kinase were also determined in the serums of dogs. Results：Danhong for injection （2,6 and 12mg/kg） by the way of intravenous injection obviously reduced the extent of myocardial infarction and the myocardial ischemia level at a dose-dependent manner. Increase of ∑-ST and N-ST, and the range of myocardial infarction caused by ligating coronary artery in dogs were obviously reduced by Danhong for injection. The level of LDH and CK in the serum of dogs were also decreased by Danhong for injection. Conclusions：The results show that Danhong for injection has significant protective effects on myocardial infarction in dogs.
出处
《药学实践杂志》
CAS
2009年第5期334-336,352,共4页
Journal of Pharmaceutical Practice
关键词
注射用丹红
心肌梗塞
肌酸激酶
乳酸脱氢酶
Danhong for injectionr
myocardial infarction
creatine kinase
lactate dehydrogenase
