摘要
目的通过对蛋白酪氨酸磷酸酶(PTEN)蛋白和α甲酰基辅酶A消旋酶(P504S/AMACR)在前列腺癌组织中表达的研究探讨两者在前列腺癌中的相关性及临床意义。方法采用免疫组织化学SABC法检测49例前列腺癌(PCA)及22例良性前列腺组织标本(BPH)中PTEN和P504S的表达情况。结果前列腺癌组织中PTEN阳性表达率为26.5%,明显低于对照组(95.5%),而P504S阳性表达率为89.8%,明显高于对照组(9.1%),差异均具有显著性(P<0.01)。PTEN蛋白的阳性表达与前列腺癌的分级、临床分期均密切相关,差异具有显著性.P504S的阳性表达与前列腺癌组织的分级相关,但与临床分期没有关联。结论PTEN蛋白和P504S(AMACR)在前列腺癌中分别呈低表达和高表达,两者的表达无明显相关,此外,它们的异常表达在前列腺癌的发生、发展中起重要作用,检测两者的表达有助于判断病情及预后。
Objective To investigate the relationship and clinical significance of PTEN and P504S in prostate carcinoma（PCA）. Methods The expressions of PTEN and P504S in 49 prostate carcinoma tissues and 22 normal prostate tissues were detected respectively by immunohistochemistry. Results The positive rate of PTEN in PCA group（26.5%） was obviously lower than that of the normal group （95.5%）. But the positive rate of P504S in PCA group （89.8%） was,significantly higher than that of the normal group（9.1%）. There were significant differences in PTEN and P504S expression between two groups（P〈0.01）. The expression level of PTEN was closely related with pathological grades of PCA and its clinical stages. The expression level of P504S was related with pathological grades of PCA, no relationship with the clinical stages was found. Conclusion Low expression of PTEN and high expression P504S was all found in PCA. There was no correlation in their expression level. However, their abnormal expression might play an important role in the carcinogenesis and development of PCA and have a potential application in prediction of tumor development and prognosis.
出处
《中国男科学杂志》
CAS
CSCD
2009年第10期18-20,25,共4页
Chinese Journal of Andrology
