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甲钴胺对合并高同型半胱氨酸血症的血管性痴呆的干预研究 被引量：2

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摘要 目的探讨甲钴胺干预治疗对合并高同型半胱氨酸血症的血管性痴呆患者的影响。方法收集128例血管性痴呆患者,分为甲组(合并高同型半胱氨酸血症)和乙组(非高同型半胱按酸血症),两组均进行基础治疗并评估MMSE、Hachinski缺血积分、CDR情况,同时对甲组进行甲钴胺干预治疗12周(0.5mgTid),分别于4周、8周和12周时复测两组血Hcy水平并评估MMSE、Hachinski缺血积分(HIS)、CDR情况。结果治疗前,甲组血Hcy水平(36.78±10.73),乙组(13.04±5.88),两组差异有统计学意义(P<0.05),MMSE、Hachinski缺血积分(HIS)、CDR评分甲组分别为(15.56±5.23)、(9.32±1.56)、(8.26±1.15),乙组分别为(16.99±6.64)、(9.61±2.04)、(8.31±1.34),两组差异无统计学意义(P>0.05);治疗后12周,甲组血Hcy水平(13.84±8.32),乙组(11.97±8.12),两组差异有统计学意义(P<0.05);CDR评分甲组(7.76±1.06),乙组(8.29±1.59),两组差异有统计学意义(P<0.05)。结论甲钴胺可降低血管性痴呆患者血Hcy水平,可在一定程度上延缓认知功能恶化。
作者 陈金梅 周维智 秦琦
机构地区 上海普陀区人民医院神经内科
出处 《卒中与神经疾病》 2009年第5期316-318,共3页 Stroke and Nervous Diseases
关键词 同型半胱氨酸 血管性痴呆 甲钴胺
分类号 R749.13 [医药卫生—神经病学与精神病学]
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参考文献10

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共引文献202

同被引文献29

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卒中与神经疾病
2009年 第5期

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