摘要
目的:探讨了慢性阻塞性肺疾病(COPD)患者治疗前后血清IL-10、IL-18和TNF-α水平的变化及意义。方法:应用放射免疫分析和酶免法对31例COPD患者进行了治疗前后血清IL-10、IL-18和TNF-α检测,并与35名正常健康人作比较。结果:COPD患者在治疗前血清IL-10、IL-18和TNF-α水平非常显著地高于正常人组(P<0.01),综合治疗后2周,与正常人组比较仍有显著性差异(P<0.05)。结论:血清IL-10、IL-18和TNF-α可能以不同的方式参与了COPD的发病,其检测对于了解病情、指导治疗具有重要的临床价值。
Objective To explore the significance of changes of serum IL-10,IL-18 and TNF-α levels after treatment in patients with chronic obstructive pulmonary diseases（COPD）.Methods Serun IL-10,TNF-α（with RIA） and IL-18（with ELISA） levels were detected both before and after treatment in 31 patients with COPD as well as in 35 controls.Results Before treatment,serum levels of IL-10,IL-18 and TNF-α were significantly higher in the patients than those in controls（P〈0.01）.After 2 weeks of treatment,the serum IL-10,IL-18 and TNF-α levels,though dropped markedly,still remained significantly higher than those in controls（P〈0.05）.Conclusion Serum IL-10,IL-18 and TNF-α could take part in the pathogenesis of COPD in various ways and determination of levels of these cytokines is clinically important.
出处
《放射免疫学杂志》
CAS
2009年第4期338-340,共3页
Journal of Radioimmanology
